Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/85784
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Type: Journal article
Title: Inhibition of human polymorphonuclear leukocyte respiratory burst, bactericidal activity, and migration by pneumolysin
Author: Paton, J.
Ferrante, A.
Citation: Infection and Immunity, 1983; 41(3):1212-1216
Publisher: American Society for Microbiology
Issue Date: 1983
ISSN: 0019-9567
1098-5522
Statement of
Responsibility: 
James C. Paton and Antonio Ferrante
Abstract: The in vitro effects of pneumolysin, a sulfhydryl-activated toxin produced by Streptococcus pneumoniae, on various functions of human polymorphonuclear leukocytes (PMNLs) was investigated. Treatment of PMNLs with highly purified toxin significantly inhibited respiratory burst (in response to stimulation), ability to kill opsonized pneumococci, chemotaxis, and random migration. These inhibitions were observed at very low toxin doses (less than or equal to 1 hemolytic unit (2 ng) per 10(6) PMNLs), which had no effect on PMNL viability. These results suggest that pneumolysin could function in pathogenicity by interfering with the ability of PMNLs to migrate toward and kill pneumococci.
Keywords: Neutrophils; Humans; Hydrogen Peroxide; Bacterial Proteins; Streptolysins; Cell Migration Inhibition; Chemotaxis, Leukocyte; Phagocytosis; Oxygen Consumption; Dose-Response Relationship, Drug
Rights: © 1983, American Society for Microbiology
RMID: 0030008956
DOI: 10.1128/iai.41.3.1212-1216.1983
Published version: http://iai.asm.org/content/41/3/1212
Appears in Collections:Molecular and Biomedical Science publications

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