Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
|Title:||Inhibition of human polymorphonuclear leukocyte respiratory burst, bactericidal activity, and migration by pneumolysin|
|Citation:||Infection and Immunity, 1983; 41(3):1212-1216|
|Publisher:||American Society for Microbiology|
|James C. Paton and Antonio Ferrante|
|Abstract:||The in vitro effects of pneumolysin, a sulfhydryl-activated toxin produced by Streptococcus pneumoniae, on various functions of human polymorphonuclear leukocytes (PMNLs) was investigated. Treatment of PMNLs with highly purified toxin significantly inhibited respiratory burst (in response to stimulation), ability to kill opsonized pneumococci, chemotaxis, and random migration. These inhibitions were observed at very low toxin doses (less than or equal to 1 hemolytic unit (2 ng) per 10(6) PMNLs), which had no effect on PMNL viability. These results suggest that pneumolysin could function in pathogenicity by interfering with the ability of PMNLs to migrate toward and kill pneumococci.|
|Keywords:||Neutrophils; Humans; Hydrogen Peroxide; Bacterial Proteins; Streptolysins; Cell Migration Inhibition; Chemotaxis, Leukocyte; Phagocytosis; Oxygen Consumption; Dose-Response Relationship, Drug|
|Rights:||© 1983, American Society for Microbiology|
|Appears in Collections:||Molecular and Biomedical Science publications|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.