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https://hdl.handle.net/2440/85965
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Type: | Journal article |
Title: | Genetic diversity and virulence potential of shiga toxin-producing Escherichia coli O113: H21 strains isolated from clinical, environmental, and food sources |
Author: | Feng, P. Delannoy, S. Lacher, D. dos Santos, L. Beutin, L. Fach, P. Rivas, M. Hartland, E. Paton, A. Guth, B. |
Citation: | Applied and Environmental Microbiology, 2014; 80(15):4757-4763 |
Publisher: | American Society for Microbiology |
Issue Date: | 2014 |
ISSN: | 0099-2240 1098-5336 |
Editor: | Björkroth, J. |
Statement of Responsibility: | Peter C. H. Feng, Sabine Delannoy, David W. Lacher, Luis Fernando dos Santos, Lothar Beutin, Patrick Fach, Marta Rivas, Elizabeth L. Hartland, Adrienne W. Paton and Beatriz E. C. Guth |
Abstract: | Shiga toxin-producing Escherichia coli strains of serotype O113:H21 have caused severe human diseases, but they are unusual in that they do not produce adherence factors coded by the locus of enterocyte effacement. Here, a PCR microarray was used to characterize 65 O113:H21 strains isolated from the environment, food, and clinical infections from various countries. In comparison to the pathogenic strains that were implicated in hemolytic-uremic syndrome in Australia, there were no clear differences between the pathogens and the environmental strains with respect to the 41 genetic markers tested. Furthermore, all of the strains carried only Shiga toxin subtypes associated with human infections, suggesting that the environmental strains have the potential to cause disease. Most of the O113:H21 strains were closely related and belonged in the same clonal group (ST-223), but CRISPR analysis showed a great degree of genetic diversity among the O113:H21 strains. |
Keywords: | Feces Animals Cattle Goats Dogs Humans Escherichia coli Infections Escherichia coli Proteins Shiga Toxin Virulence Factors Environmental Microbiology Food Microbiology Phylogeny Meat Molecular Sequence Data Shiga-Toxigenic Escherichia coli Genetic Variation |
Description: | Published ahead of print 23 May 2014 |
Rights: | © 2014, American Society for Microbiology. All Rights Reserved. |
DOI: | 10.1128/AEM.01182-14 |
Published version: | http://dx.doi.org/10.1128/aem.01182-14 |
Appears in Collections: | Aurora harvest 7 Molecular and Biomedical Science publications |
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