Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
|Title:||Chlorhexidine affects arginine metabolism as well as glycolysis in a strain of Streptococcus sanguis|
|Citation:||Oral Microbiology and Immunology, 1987; 2(4):178-182|
|A. H. Rogers, P. S. Ziltn, N. J. Gully, A. L. Pfennig|
|Abstract:||Abstract The effect of Chlorhexidine digluconate (CHX) on the uptake and catabolism of arginine (arg) by Streptococcus sanguis P4A7 was investigated since the ability to use this amino acid may play a role in its existence in dental plaque. Organisms were grown glucose-limited in continuous culture in a chemically-defined medium. Washed cells, resuspended in a salt solution, were exposed to various concentrations of CHX prior to the addition of arg. Uptake of arginine and the appearance of its catabolites were monitored by HPLC analysis of cell suspension filtrates. At pH 7.0 and 5.5, both uptake and breakdown were progressively reduced by 0.06 and 0.12 mM CHX and these effects were even more marked in the presence of 0.24 mM CHX, which also reduced cell viability. The glycolytic rate was also progressively reduced as the level of CHX was raised from 0.06 to 0.24 mM. The arginine deiminase pathway, as well as glycolysis, is thus depressed by sub-inhibitory concentrations of CHX and it is suggested that this could have far-reaching effects on overall plaque metabolism.|
|Keywords:||Chlorhexidine; arginine metabolism; Streptococcus sanguis|
|Rights:||Copyright status unknown|
|Appears in Collections:||Dentistry publications|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.