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Type: Journal article
Title: Fabrication and characterisation of an electrospun tubular 3D scaffold platform of poly(vinylidene fluoride-co-hexafluoropropylene) for small-diameter blood vessel application
Author: Ahmed, F.
Roy Choudhury, N.
Dutta, N.
Zou, L.
Zannettino, A.
Citation: Journal of Biomaterials Science: Polymer Edition, 2014; 25(18):2023-2041
Publisher: Taylor & Francis
Issue Date: 2014
ISSN: 0920-5063
Statement of
Furqan Ahmed, Namita Roy Choudhury, Naba K. Dutta, Linda Zou & Andrew Zannettino
Abstract: In this research, nanofibrous 3D tubular (~4-mm-diameter tube) scaffolds of poly (vinylidene fluoride-co-hexafluoropropylene) were fabricated by electrospinning. The role of surface charge in the success of these scaffolds for potential small-diameter artificial vascular grafts has been investigated using streaming potential study. Prior to endothelial cell culture, surface properties such as wettability and the surface charge of these tubular scaffolds were evaluated using unmodified and fibrinogen-adsorbed surfaces to understand their interaction with surrounding environment. The tubular scaffolds constructed using electrospinning show similar mechanical properties such as tensile strength and elastic modulus as those of native vessels. Whilst endothelial cell proliferation on unmodified tubes, as analysed by scanning electron microscopy, was found to be moderate, a simple process of dynamic fibrinogen adsorption was seen to enhance the endothelialisation of these tubular grafts. The high negative zeta potential values, high strength, robustness and structural reliability of the scaffolds represent them to be promising biomaterials for vascular graft applications.
Keywords: electrospinning; SEM; poly(vinylidene fluoride-co-hexafluoropropylene); fibres; zeta potential; platelets; vascular graft
Description: Supplemental data for this article can be accessed at
Rights: © 2014 Taylor & Francis
DOI: 10.1080/09205063.2014.968018
Grant ID: ARC
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