Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/94118
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kaidonis, G. | - |
dc.contributor.author | Abhary, S. | - |
dc.contributor.author | Daniell, M. | - |
dc.contributor.author | Gillies, M. | - |
dc.contributor.author | Fogarty, R. | - |
dc.contributor.author | Petrovsky, N. | - |
dc.contributor.author | Jenkins, A. | - |
dc.contributor.author | Essex, R. | - |
dc.contributor.author | Chang, J. | - |
dc.contributor.author | Pal, B. | - |
dc.contributor.author | Hewitt, A. | - |
dc.contributor.author | Burdon, K. | - |
dc.contributor.author | Craig, J. | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Clinical and Experimental Ophthalmology, 2014; 42(5):486-493 | - |
dc.identifier.issn | 1442-6404 | - |
dc.identifier.issn | 1442-9071 | - |
dc.identifier.uri | http://hdl.handle.net/2440/94118 | - |
dc.description.abstract | BACKGROUND: Diabetic retinopathy (DR) is a blinding disease of increasing prevalence that is caused by a complex interplay of genetic and environmental factors. Here we describe the patient recruitment methodology, case and control definitions, and clinical characteristics of a study sample to be used for genome-wide association analysis to detect genetic risk variants of DR. METHODS: One thousand six hundred sixty-nine participants with either type 1 (T1) or type 2 (T2) diabetes mellitus (DM) aged 18 to 95 years were recruited in Australian hospital clinics. Individuals with T2DM had disease duration of at least 5 years and were taking oral hypoglycaemic medication, and/or insulin therapy. Participants underwent ophthalmic examination. Medical history and biochemistry results were collected. Venous blood was obtained for genetic analysis. RESULTS: Six hundred eighty-three diabetic cases (178 T1DM and 505 T2DM participants) with sight-threatening DR, defined as severe non-proliferative DR, proliferative DR or diabetic macular oedema were included in this analysis. Eight hundred twelve individuals with DM but no DR or minimal non-proliferative DR were recruited as controls (191 with T1DM and 621 with T2DM). The presence of sight-threatening DR was significantly correlated with DM duration, hypertension, nephropathy, neuropathy, HbA1C and body mass index. Diabetic macular oedema was associated with T2DM (P < 0.001), whereas proliferative DR was associated with T1DM (P < 0.001). CONCLUSIONS: Adoption of a case-control study design involving extremes of the DR phenotype makes this a suitable cohort, for a well-powered genome-wide association study to detect genetic risk variants for DR. | - |
dc.description.statementofresponsibility | Georgia Kaidonis, Sotoodeh Abhary, Mark Daniell, Mark Gillies, Rhys Fogarty, Nikolai Petrovsky, Alicia Jenkins, Rohan Essex, John H Chang, Bishwanath Pal, Alex W Hewitt, Kathryn P Burdon and Jamie E Craig | - |
dc.language.iso | en | - |
dc.publisher | Wiley | - |
dc.rights | © 2013 Royal Australian and New Zealand College of Ophthalmologists | - |
dc.source.uri | http://dx.doi.org/10.1111/ceo.12239 | - |
dc.subject | diabetic macular oedema; diabetic retinopathy; genome-wide association study | - |
dc.title | Genetic study of diabetic retinopathy: recruitment methodology and analysis of baseline characteristics | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1111/ceo.12239 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/595918 | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest 7 Opthalmology & Visual Sciences publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.