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Type: Journal article
Title: Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity
Author: Cousminer, D.
Berry, D.
Timpson, N.
Ang, W.
Thiering, E.
Byrne, E.
Taal, H.
Huikari, V.
Bradfield, J.
Kerkhof, M.
Groen-Blokhuis, M.
Kreiner-Møller, E.
Marinelli, M.
Holst, C.
Leinonen, J.
Perry, J.
Surakka, I.
Kettunen, J.
Anttila, V.
Kaakinen, M.
et al.
Citation: Human Molecular Genetics, 2013; 22(13):2735-2747
Publisher: Oxford University Press
Issue Date: 2013
ISSN: 0964-6906
Statement of
Diana L. Cousminer ... Lyle J. Palmer ... The ReproGen Consortium ... et al. for the Early Growth Genetics (EGG) Consortium
Abstract: The pubertal height growth spurt is a distinctive feature of childhood growth reflecting both the central onset of puberty and local growth factors. Although little is known about the underlying genetics, growth variability during puberty correlates with adult risks for hormone-dependent cancer and adverse cardiometabolic health. The only gene so far associated with pubertal height growth, LIN28B, pleiotropically influences childhood growth, puberty and cancer progression, pointing to shared underlying mechanisms. To discover genetic loci influencing pubertal height and growth and to place them in context of overall growth and maturation, we performed genome-wide association meta-analyses in 18 737 European samples utilizing longitudinally collected height measurements. We found significant associations (P < 1.67 × 10−8) at 10 loci, including LIN28B. Five loci associated with pubertal timing, all impacting multiple aspects of growth. In particular, a novel variant correlated with expression of MAPK3, and associated both with increased prepubertal growth and earlier menarche. Another variant near ADCY3-POMC associated with increased body mass index, reduced pubertal growth and earlier puberty. Whereas epidemiological correlations suggest that early puberty marks a pathway from rapid prepubertal growth to reduced final height and adult obesity, our study shows that individual loci associating with pubertal growth have variable longitudinal growth patterns that may differ from epidemiological observations. Overall, this study uncovers part of the complex genetic architecture linking pubertal height growth, the timing of puberty and childhood obesity and provides new information to pinpoint processes linking these traits.
Keywords: ReproGen Consortium; Early Growth Genetics (EGG) Consortium; Humans; Neoplasms; Mitogen-Activated Protein Kinase 3; Transforming Growth Factor beta; Body Mass Index; Body Height; Follow-Up Studies; Age Factors; Signal Transduction; Gene Expression; Puberty; Menarche; Phenotype; Quantitative Trait Loci; Adolescent; Child; Female; Male; Adiposity; Genome-Wide Association Study; Young Adult; Genetic Linkage
Rights: © The Author 2013. Published by Oxford University Press. All rights reserved. For Permissions, please email:
RMID: 0020136597
DOI: 10.1093/hmg/ddt104
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Appears in Collections:Public Health publications

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