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https://hdl.handle.net/2440/53528
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dc.contributor.author | Parker, D. | - |
dc.contributor.author | Marino, V. | - |
dc.contributor.author | Ong, J. | - |
dc.contributor.author | Puspawati, N. | - |
dc.contributor.author | Prager, R. | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | Clinical and Experimental Pharmacology and Physiology, 2008; 35(9):1113-1115 | - |
dc.identifier.issn | 0305-1870 | - |
dc.identifier.issn | 1440-1681 | - |
dc.identifier.uri | http://hdl.handle.net/2440/53528 | - |
dc.description | The definitive version may be found at www.wiley.com | - |
dc.description.abstract | The pharmacological actions of 2,6-di-tert-butyl-4-(3-hydroxy-2-spiropentylpropyl)-phenol (BSPP), a putative presynaptic GABA(B) receptor modulator, were examined in electrically stimulated rat neocortical brain slices preloaded with [3H]-GABA or [3H]-glutamic acid. At 10 mmol/L, BSPP inhibited the release of [3H]-GABA in the presence of baclofen, but not that of [3H]-glutamic acid. This effect was sensitive to the GABA(B) receptor antagonist (+)-(S)-5,5-dimethylmorpholinyl-2-acetic acid (Sch 50911). Alone, BSPP had no effect on the release of [3H]-GABA or [3H]-glutamic acid. It is concluded that BSPP selectively potentiates the action of baclofen at GABA(B) autoreceptors, but not heteroreceptors and may be a useful ligand to discriminate between presynaptic GABA(B) receptor subtypes. | - |
dc.description.statementofresponsibility | David AS Parker, Victor Marino, Jennifer Ong, Ni Made Puspawati and Rolf H Prager | - |
dc.language.iso | en | - |
dc.publisher | Blackwell Publishing Asia | - |
dc.source.uri | http://dx.doi.org/10.1111/j.1440-1681.2008.04948.x | - |
dc.subject | Neocortex | - |
dc.subject | Animals | - |
dc.subject | Rats | - |
dc.subject | Rats, Sprague-Dawley | - |
dc.subject | Tritium | - |
dc.subject | gamma-Aminobutyric Acid | - |
dc.subject | Baclofen | - |
dc.subject | Phenols | - |
dc.subject | Morpholines | - |
dc.subject | Spiro Compounds | - |
dc.subject | Glutamic Acid | - |
dc.subject | Receptors, GABA-B | - |
dc.subject | Organ Culture Techniques | - |
dc.subject | Drug Evaluation, Preclinical | - |
dc.subject | Drug Synergism | - |
dc.subject | Male | - |
dc.subject | GABA-B Receptor Antagonists | - |
dc.title | The CGP7930 analogue 2,6-di-tert-butyl-4-(3-hydroxy-2-spiropentylpropyl)-phenol (BSPP) potentiates baclofen action at GABA(B) autoreceptors | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1111/j.1440-1681.2008.04948.x | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Ong, J. [0000-0002-0958-460X] | - |
Appears in Collections: | Aurora harvest Medicine publications |
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