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https://hdl.handle.net/2440/72884
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dc.contributor.author | Selth, L. | - |
dc.contributor.author | Townley, S. | - |
dc.contributor.author | Gillis, J. | - |
dc.contributor.author | Ochnik, A. | - |
dc.contributor.author | Murti, K. | - |
dc.contributor.author | Macfarlane, R. | - |
dc.contributor.author | Chi, K. | - |
dc.contributor.author | Marshall, V. | - |
dc.contributor.author | Tilley, W. | - |
dc.contributor.author | Butler, L. | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | International Journal of Cancer, 2012; 131(3):652-661 | - |
dc.identifier.issn | 0020-7136 | - |
dc.identifier.issn | 1097-0215 | - |
dc.identifier.uri | http://hdl.handle.net/2440/72884 | - |
dc.description.abstract | Circulating microRNAs (miRNAs) are emerging as useful non-invasive markers of disease. The objective of this study was to use a mouse model of prostate cancer as a tool to discover serum miRNAs that could be assessed in a clinical setting. Global miRNA profiling identified 46 miRNAs at significantly altered levels (p < 0.05) in the serum of TRansgenic Adenocarcinoma of Mouse Prostate (TRAMP) mice with advanced prostate cancer compared to healthy controls. A subset of these miRNAs with known human homologues were validated in an independent cohort of mice and then measured in serum from men with metastatic castration-resistant prostate cancer (mCRPC; n 5 25) or healthy men (n 5 25). Four miRNAs altered in mice, mmumiR- 141, mmu-miR-298, mmu-miR-346 and mmu-miR-375, were also found to be at differential levels in the serum of men with mCRPC. Three of these (hsa-miR-141, hsa-miR-298 and hsa-miR-375) were upregulated in prostate tumors compared with normal prostate tissue, suggesting that they are released into the blood as disease progresses. Moreover, the intra-tumoral expression of hsa-miR-141 and hsa-miR-375 were predictors of biochemical relapse after surgery. This study is the first to demonstrate that specific serum miRNAs are common between human prostate cancer and a mouse model of the disease, highlighting the potential of such models for the discovery of novel biomarkers. | - |
dc.description.statementofresponsibility | Luke A. Selth, Scott Townley, Joanna L. Gillis, Aleksandra M. Ochnik, Krisna Murti, Robyn J. Macfarlane, Kim N. Chi, Villis R. Marshall, Wayne D. Tilley and Lisa M. Butler | - |
dc.language.iso | en | - |
dc.publisher | Wiley-liss | - |
dc.rights | Copyright © 2011 UICC | - |
dc.source.uri | http://dx.doi.org/10.1002/ijc.26405 | - |
dc.subject | Animals | - |
dc.subject | Mice, Inbred C57BL | - |
dc.subject | Mice, Transgenic | - |
dc.subject | Humans | - |
dc.subject | Mice | - |
dc.subject | Prostatic Neoplasms | - |
dc.subject | MicroRNAs | - |
dc.subject | Prognosis | - |
dc.subject | Oligonucleotide Array Sequence Analysis | - |
dc.subject | Gene Expression Profiling | - |
dc.subject | Male | - |
dc.subject | Biomarkers, Tumor | - |
dc.title | Discovery of circulating microRNAs associated with human prostate cancer using a mouse model of disease | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1002/ijc.26405 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/627185 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Selth, L. [0000-0002-4686-1418] | - |
dc.identifier.orcid | Tilley, W. [0000-0003-1893-2626] | - |
dc.identifier.orcid | Butler, L. [0000-0003-2698-3220] | - |
Appears in Collections: | Aurora harvest 5 Medicine publications |
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