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https://hdl.handle.net/2440/9360
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dc.contributor.author | O'Reilly, L. | - |
dc.contributor.author | Ekert, P. | - |
dc.contributor.author | Harvey, N. | - |
dc.contributor.author | Marsden, V. | - |
dc.contributor.author | Cullen, L. | - |
dc.contributor.author | Vaux, D. | - |
dc.contributor.author | Hacker, G. | - |
dc.contributor.author | Magnusson, C. | - |
dc.contributor.author | Pakusch, M. | - |
dc.contributor.author | Cecconi, F. | - |
dc.contributor.author | Kuida, K. | - |
dc.contributor.author | Strasser, A. | - |
dc.contributor.author | Huang, D. | - |
dc.contributor.author | Kumar, S. | - |
dc.date.issued | 2002 | - |
dc.identifier.citation | Cell Death and Differentiation, 2002; 9(8):832-841 | - |
dc.identifier.issn | 1350-9047 | - |
dc.identifier.issn | 1476-5403 | - |
dc.identifier.uri | http://hdl.handle.net/2440/9360 | - |
dc.description.abstract | We have generated rat monoclonal antibodies that specifically recognise caspase-2 from many species, including mouse, rat and humans. Using these antibodies, we have investigated caspase-2 expression, subcellular localisation and processing. We demonstrate that caspase-2 is expressed in most tissues and cell types. Cell fractionation and immunohistochemistry experiments show that caspase-2 is found in the nuclear and cytosolic fractions, including a significant portion present in the Golgi complex. We found that caspase-2 is processed in response to many apoptotic stimuli but experiments with caspase-2 deficient mice demonstrated that it is not required for apoptosis of thymocytes or dorsal root ganglia (DRG) neurons in response to a variety of cytotoxic stimuli. Caspase-2 processing does not occur in thymocytes lacking Apaf-1 or caspase-9, suggesting that in this cell type, activation of caspase-2 occurs downstream of apoptosome formation. | - |
dc.language.iso | en | - |
dc.publisher | Nature Publishing Group | - |
dc.source.uri | http://dx.doi.org/10.1038/sj.cdd.4401033 | - |
dc.subject | Ganglia, Spinal | - |
dc.subject | Neurons | - |
dc.subject | T-Lymphocytes | - |
dc.subject | Hela Cells | - |
dc.subject | Cell Nucleus | - |
dc.subject | Golgi Apparatus | - |
dc.subject | Animals | - |
dc.subject | Mice, Inbred C57BL | - |
dc.subject | Mice, Knockout | - |
dc.subject | Humans | - |
dc.subject | Mice | - |
dc.subject | Rats | - |
dc.subject | Rats, Wistar | - |
dc.subject | Caspases | - |
dc.subject | Proteins | - |
dc.subject | Antibodies, Monoclonal | - |
dc.subject | Signal Transduction | - |
dc.subject | Apoptosis | - |
dc.subject | Antibody Specificity | - |
dc.subject | Gene Expression Regulation, Enzymologic | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.subject | Caspase 9 | - |
dc.subject | Apoptotic Protease-Activating Factor 1 | - |
dc.subject | Caspase 2 | - |
dc.title | Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9 | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1038/sj.cdd.4401033 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Harvey, N. [0000-0001-9839-8966] | - |
dc.identifier.orcid | Kumar, S. [0000-0001-7126-9814] | - |
Appears in Collections: | Aurora harvest Medicine publications |
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