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https://hdl.handle.net/2440/9584
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Type: | Journal article |
Title: | Effect of lipase inhibition on gastric emptying of, and the glycemic and incretin responses to, an oil/aqueous drink in type 2 diabetes mellitus |
Author: | Pilichiewicz, A. O'Donovan, D. Feinle-Bisset, C. Lei, Y. Wishart, J. Bryant, L. Meyer, J. Horowitz, M. Jones, K. |
Citation: | Journal of Clinical Endocrinology and Metabolism, 2003; 88(8):3829-3834 |
Publisher: | Endocrine Society |
Issue Date: | 2003 |
ISSN: | 0021-972X 1945-7197 |
Statement of Responsibility: | A. Pilichiewicz, D. O’Donovan, C. Feinle, Y. Lei, J. M. Wishart, L. Bryant, J. H. Meyer, M. Horowitz, and K. L. Jones |
Abstract: | This study examined the effects of the lipase inhibitor, orlistat, on gastric emptying of, and the glycemic and incretin hormone responses to, a drink containing oil and glucose components in patients with type 2 diabetes. Seven patients (aged 58 +/- 5 yr), managed by diet alone, consumed 60 ml olive oil (labeled with 20 MBq (99m)Tc-V-thiocyanate) and 300 ml water containing 75 g glucose (labeled with 6 MBq (67)Ga-EDTA), on two occasions, with and without 120 mg orlistat, positioned in the left lateral decubitus position with their back against a gamma camera. Venous blood samples, for measurement of blood glucose and plasma insulin, glucagon-like peptide-1 and glucose-dependent insulintropic polypeptide were obtained immediately before, and after, the drink. Gastric emptying of both oil (P < 0.001) and glucose (P < 0.0005) was faster after orlistat compared with control. Postprandial blood glucose (P < 0.001) and plasma insulin (P < 0.05) were substantially greater after orlistat compared with control. In contrast, plasma glucagon-like peptide-1 (P < 0.005) and glucose-dependent insulintropic polypeptide (P < 0.05) were less after orlistat. In conclusion, inhibition of fat digestion, by orlistat, may exacerbate postprandial glycemia, as a result of more rapid gastric emptying and a diminished incretin response. |
Keywords: | Gastric Mucosa Autonomic Nervous System Humans Diabetes Mellitus, Type 2 Lactones Gastric Inhibitory Polypeptide Glucagon Insulin Lipase Glucose Blood Glucose Dietary Fats Peptides Peptide Fragments Enzyme Inhibitors Gastric Emptying Middle Aged Female Male Glucagon-Like Peptide 1 Glucagon-Like Peptides Hemodynamics Orlistat |
Rights: | © 2003 by The Endocrine Society |
DOI: | 10.1210/jc.2003-030199 |
Published version: | http://jcem.endojournals.org/cgi/content/abstract/88/8/3829 |
Appears in Collections: | Aurora harvest Medicine publications |
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