Adelaide Research & Scholarship
Adelaide Research & Scholarship (AR&S) is the University of Adelaide’s digital repository. AR&S provides a platform for the collection, organisation, access and preservation of the research and scholarly outputs of the University community in digital formats, as well as digital management of information in physical formats.
University of Adelaide higher degree by research theses are deposited into the AR&S Theses community as part of the final thesis lodgement process.
AR&S also serves as the home of the digital collections of University Library Archives and Special Collections. Items include digitized representations of physical items, such as photographs and full texts, and digital-born materials, allowing worldwide access to our heritage and research collections.
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Recent Submissions
Quality indicators for safe and effective use of medications in long-term care settings: A systematic review
(Wiley, 2025) Gutteridge, D.S.; Calder, A.H.; Stasinopoulos, J.; Javanparast, S.; Caughey, G.E.; Hillen, J.B.; Stafford, A.C.; Peterson, G.M.; Inacio, M.C.; Khadka, J.; Kalisch Ellett, L.M.; Jackson, S.L.; Hibbert, P.D.; Cations, M.L.; Corlis, M.E.; Yu, S.C.; Clark, M.J.; Soulsby, N.R.; Manias, E.; Yoo, G.H.Y.; et al.
People accessing aged care services are increasingly older and often experience multimorbidity and polypharmacy, which puts them at risk of medication-related harm. Quality indicators (QIs) can assist with monitoring, benchmarking and informing initiatives to reduce medication-related harm. This systematic review aimed to identify and summarize QIs that assess the safe and effective use of medications in long-term care services. Bibliographic databases and grey literature were searched to identify relevant QIs. Eligible publications were in English and described the development, application and/or validation of QIs in long-term care facilities or in-home aged care services. QI information, including their development and settings, were extracted. All QIs were classified according to 3 validated classification systems and grouped by themes constructed from the review. From the 62 academic articles and 16 grey literature documents included, 53 QI sets were extracted, which comprised 442 individual QIs and 18 potentially inappropriate medication lists were identified. Most (80%, n = 354) QIs were process indicators. About 1/4 (26%, n = 115) were medication-specific QIs focusing mainly on prevalence of use and dosing, with similar numbers for infection prevention and control (25%, n = 112). A smaller proportion (7%, n = 32) of QIs encompassed person-centred measures such as resident involvement in medication-related decisions. This comprehensive overview of contemporary QIs to monitor medication safety and effectiveness across long-term care services can help clinicians, aged care providers and policy makers to identify important measures to employ in aged care settings to monitor and influence care improvements.
Rationale and Design of the Cessation Of Pharmacotherapy In Recovered Chemotherapy-induced cardioToxicity (COP-RCT): A Pilot Study
(Elsevier, 2024) Yu, C.; Negishi, T.; Pathan, F.; Sverdlov, A.; Thomas, L.; Shirazi, M.; Koo, C.Y.; Tan, L.L.; Miyazaki, S.; Negishi, K.
Background Cancer therapeutics-related cardiac dysfunction (CTRCD) is a well-recognised complication of cancer treatment. Treatment of CTRCD involves cardioprotective therapy (CPT) which can lead to a recovery of CTRCD with normalisation of the left ventricular ejection fraction (LVEF). As a result, there are potentially millions of cancer survivors with recovered CTRCD on CPT. Cardioprotective therapy can be associated with an undesirable long-term pill burden, financial costs, and side effects. Cancer survivorship is anticipated to increase significantly by the end of this decade. To date, there is no evidence of the safety of stopping CPT in this setting. This study seeks to evaluate the hypothesis that ceasing cardioprotective medication is a feasible and safe option without significant impact on LVEF in low-risk patients who have recovered from CTRCD. Methods and Analysis We will perform a multicentre prospective open-label randomised controlled trial with blinded endpoint (PROBE) of supervised CPT cessation compared to continuing CPT (control). The primary study end point is the change in LVEF by cardiac magnetic resonance imaging at 6 months of enrolment between the two groups. Secondary end points include changes in quality-of-life questionnaires, other cardiac imaging parameters, and recurrence of heart failure. Conclusion Cessation Of Pharmacotherapy In Recovered Chemotherapy-induced cardioToxicity (COP-RCT) is one of the first studies currently underway to evaluate the safety of ceasing CPT in recovered CTRCD. The results will inform clinical practice in this evidence-free zone.
Relaxing constraints on a broad dark photon
(American Physical Society, 2025) Felix, J.R.; Thomas, A.W.; Wang, X.G.
We revisit the exclusion constraints on the parameters of a narrow dark photon set by direct experimental searches. We investigate how a dark photon with a larger decay width impacts these limits, in particular, in the case where the dark photon also decays into light dark matter. As an example, taking the upper limits on the mixing parameter, 𝜀, reported by the CMS Collaboration, we find that they could be significantly relaxed. Indeed, even a very modest coupling of the dark photon to dark matter can lead to an increase in the bound on the mixing parameter by an order of magnitude.
Erasure and agency in sexuality and relationships education and knowledge among trans young people in Australia
(Taylor and Francis Group, 2024) Riggs, D.W.; Bellamy, R.; Wiggins, J.
Sexuality and relationship education (SRE) for trans young people is fraught with ongoing institutional and informational erasure, even as trans young people display considerable agency in navigating their SRE needs. This paper reports on a survey of 112 Australian trans young people, who shared their experiences of SRE (in terms of delivery and content), and their views on three story completion tasks where they were asked to respond to prompts about three fictional stories focused on trans young people (and for some their cisgender partners) and intimacy. Participants reported that SRE was delivered in class and focused on puberty and anatomy, although many participants accessed SRE information informally. Participants overwhelmingly reported the erasure of trans-specific SRE content and suggested that SRE content should include a trans focus. Responses to the story completion task emphasised the agency of the fictional trans young people in asserting their boundaries, deserving respect, being knowledgeable about their bodies and ensuring their safety. Fictional cisgender young people in the story completion tasks were expected to be respectful, and to be guided by trans people (but also to educate themselves). The paper concludes with recommendations for harnessing trans young people’s agency in the context of SRE.
Transformative Moral Repair Following Interpersonal Transgressions: Post-Transgression Relationship Growth.
(SAGE Publications, 2025) Quinney, B.; Wenzel, M.; Okimoto, T.G.; Thai, M.; Woodyatt, L.
Research often views relationship repair through a reparative lens of relationship partners attempting to fix what was damaged or broken by the transgression. We argue here for a transformative lens to view transgressions as potential catalysts for the strengthening of relationships or what we term: post-transgression relationship growth (PTRG). However, we also argue that PTRG is more likely achieved when the transgression is dealt with dyadically via a constructive process of coreflection. Results from a pilot study and two pre-registered three-wave longitudinal studies provided validation for a PTRG scale, which assesses relationship growth/decline after transgressions that occurred between romantic relationship partners. Moreover, co-reflection was prospectively positively associated with PTRG when controlling for baseline relationship qualities. Together, these findings highlight that relationships can emerge stronger out of relationship adversity when relationship partners engage in the constructive process of co-reflection.