Theses

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Included in the Research Theses collection are Masters, PHD and Professional Doctorate theses.
Masters and PHDs by coursework theses are included in the Honours and Coursework Theses collection. Some schools may choose to include Honours theses which make a significant contribution to knowledge.
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Browsing Theses by Advisors "Abbott, Amanda Helen"

Now showing 1 - 2 of 2
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    ItemOpen Access
    A 3D CT analysis of Malay cleft lip and palate infants.
    (2004) Rajion, Zainul Ahmad; Townsend, Grant Clement; Netherway, David John; Abbott, Amanda Helen; Shuaib, Ibrahim Lutfi; School of Dentistry
    This thesis describes the three-dimensional (3D) assessment of craniofacial structures in cleft lip and palate patients pre-operatively. The study subjects were 29 cleft lip and palate (CLP) infants of Malay origin aged between 0-12 months and 12 non-cleft (NC) infants matched for age. CT scans were obtained using a GE Lightspeed Plus Scanner. The cranio-cervical facial morphology of cleft lip and palate has been analysed using computer programs based on cephalometric landmark points in three-dimensions. Analysis of selected craniofacial and cervical regions has included: - Measurement of the position of the hyoid bone in relation to the cervical vertebrae and cranial base - Measurement of the length of the cervical spine and intervertebral spaces - Measurement of the nasopharyngeal complex - Measurement of the cranial base - Measurement of the width of spheno-occipital synchondrosis. These findings have also been associated with related clinical problems, such as aspiration pneumonia. A statistical comparison of individual cranio-cervical facial bones of cleft lip and palate infants with age-matched adjusted for the effect of sex non-cleft infants revealed areas of significant variation from normal. Very few of the study variables displayed significant differences between males and females in either the CLP or NC group. From the analyses of these areas, findings are documented and compared to those previously reported in the literature. Furthermore, previously unreported findings have been highlighted. The anomalies noted include a lower position of the hyoid bone, located at the level of C3 or C4 in the cleft lip and palate infants, whereas in the non-cleft infants, it was positioned at the much higher level of C2 or C3. In addition, 5 patients in the cleft group had significant hyoid bone abnormalities such as absent body, greater horn or overall abnormal shape. These results could be associated with compromised function of the epiglottis in forming a seal with the larynx, thereby increasing the risk of aspiration pneumonia. The findings of the cervical spine include the significantly smaller height of the vertebral bodies with larger intervertebral spaces in the cleft lip and palate infants compared with the non-cleft infants and fusion of the posterior arch of the cervical spine. The results also showed an increased pharyngeal width in the cleft lip and palate infants compared with the non-cleft infants. These anatomical variations may be associated with disruptions in the dilatory mechanism of the eustachian tube thus leading to recurrent middle ear infection in the cleft children and subsequent loss of hearing. Analysis of data on the cranial base showed a smaller cranial base that could be associated with the observed midface hypoplasia in cleft lip and palate infants that occurs with growth in these infants. Infants with cleft lip and palate had a wider spheno-occipital synchondrosis, in contrast to the narrower spheno-occipital synchondrosis reported previously with Crouzon syndrome and Apert syndrome. A wider spheno-occipital synchondrosis could be associated with dysmorphic and compensatory growth changes in later life. The observed morphological aberrations in early childhood reflect abnormalities that have developed in embryonic/foetal life. Interestingly, the isolated cleft palate group showed different results for several study variables from the other affected groups and this is consistent with its distinct aetiology. The detailed analysis of the severity and extent of the deformities provided insight into the biological basis of cleft lip and palate. The investigation has highlighted the existence of a greater range of extracranial anomalies in cleft lip and palate than previously thought and should assist clinicians in the management of affected infants. The findings should also be of interest to craniofacial developmental biologists who are investigating the complex biological processes of human development. Furthermore, the thesis provides support for the concept that cleft lip and palate is part of a broader craniofacial anomaly, not just a localised defect.
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    ItemOpen Access
    Craniofacial growth changes in Malaysian Malay children and young adults: a cross-sectional 3-dimensional CT study.
    (2007) Yusof, Asilah; Townsend, Grant Clement; Netherway, David John; Abbott, Amanda Helen; School of Dentistry
    This thesis presents a three-dimensional computed tomography (3D-CT) analysis of craniofacial morphology and growth changes in Malaysian Malay subjects. A large number of CT scans (n=205) from birth to adulthood were gathered for this purpose. CT scans were obtained using a GE Lightspeed Plus Scanner. Craniofacial morphology has been analysed based on cephalometric landmarks located in three-dimensions, using specially-designed computer software. The main aims were to produce new 3D normative reference data for selected craniofacial variables in Malaysian Malays and to study growth changes in different craniofacial regions. The specific areas of investigation included: 1. Construction of craniofacial growth references (in tabular and graphical formats) for Malaysian Malays; 2. Quantitative analysis of growth changes in the craniofacial complex using linear and angular measurements derived from landmark data; 3. Comparison of craniofacial measurements between males and females to determine the extent of sexual dimorphism; 4. Quantitative analysis of the nature and extent of directional asymmetry of selected craniofacial regions; 5. Comparisons of selected variables with published data from other ethnic groups. Craniofacial morphology and growth changes were analysed using 3D osseous landmarks. A computer program, PERSONA, was used to locate and analyse the three-dimensional cephalometric landmarks. The accuracy of landmark location was assessed using double determinations. Selected measurements were derived from the landmark data to describe the morphology of different craniofacial regions, e.g. facial skeleton, cranial base and cranial vault. Normative reference data for a large number of variables covering the skull, cranial base and face at selected age categories for males and females were constructed. These data were presented in tables and scatter plots of variables against age. From the normative data collected, patterns of growth changes of different craniofacial regions in three-dimensions were also investigated. Generally, each craniofacial region showed a unique growth pattern as observed from differential growth patterns. All measurements showed size increase from infancy to adulthood. Periods of increased size differences were also noted for most variables in all regions that corresponded to the timing of mid- and adolescent growth spurts. These extensive normative reference data, specific for age categories and sexes, provide normal references against which the craniofacial morphology of individuals with craniofacial abnormalities can be compared. Clinical applications of this quantitative approach to the craniofacial skeleton should facilitate the management of craniofacial abnormalities. Following the construction of normative data and description of growth changes for different craniofacial regions, intra-populational differences were studied. This included analysis of sexual dimorphism of the craniofacial structures and an investigation of asymmetry between paired left and right measurements. Sexual dimorphism was observed for linear variables in this study. Differences in size between males and females were not very obvious during infancy as only a few variables showed significant differences. The number of variables that showed sexual dimorphism in size increased from infancy to adulthood. Sexual dimorphism in the craniofacial region was most evident during adulthood with 46% of variables displaying significant differences between the sexes. During infancy, only 3% of the variables showed significant size differences between the sexes, increasing to 7% during childhood. Magnitudes of sexual dimorphism were calculated to highlight the pattern of dimorphism in different craniofacial regions and across different ages. A small degree of directional asymmetry was noted in all of the craniofacial regions investigated. Asymmetry analysis revealed that the cranial base, face and mandible tended to be larger on the right side than the left. Other regions exhibited asymmetry but without any clear trend in direction. Asymmetry percentages were also calculated to enable the patterns and magnitudes of asymmetry in different craniofacial regions to be compared. Generally, the amount of asymmetry exhibited in the craniofacial structures for Malaysian Malays was small. Having established that differences existed within the Malay sample, craniofacial data for Malays were compared with published data for two Caucasian populations. This analysis revealed that differences exist in craniofacial morphology between different ethnic groups. Some of the differences can be discerned from childhood but many variables only display differences during adulthood. Craniofacial structures tended to be smaller in Malays than in Caucasians. The intent of this investigation has been to provide clinicians with normative values of measurements that will be useful in diagnosis, treatment planning and post-operative care of patients with craniofacial abnormalities. Important treatment goals include producing balanced cranial and facial form to approximate that of unaffected people and also improving the quality of life of patients. Therefore, it is important for clinicians to be able to recognise the nature and extent of normal variation in craniofacial structures and also appreciate the growth changes that may occur over time, before investigating these changes in patients with craniofacial abnormalities. Comparisons of measurements of affected patients with well-characterised referent data can facilitate diagnosis and overall patient management. Moreover, quantification based on three-dimensional data provides new insights into craniofacial growth changes and morphology compared with conventional 2D approaches.