Microbiology and Immunology publications

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Browsing Microbiology and Immunology publications by Author "Adelaide Research & Innovation"

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    Cleavage of BiP by Subtilase Cytotoxin
    (2008) Paton, A.; Paton, J.; Backer, M.; Backer, J.; Adelaide Research & Innovation; Adelaide Research & Innovation Pty Ltd
    Cleavage of BIP (Immunoglobulin binding protein) by subtilase toxin and its application to inhibiting growth of or killing of cells. This has application to treatment of cancers and to conformational diseases and in particular to conformational diseases involving BiP that are influenced by cleavage by the subtilase cytotoxin. The invention also relates to subtilase toxin molecules specifically targeting proliferating cells, in particular tumor cells, or cells expressing a vascular endothelial growth factor receptor.