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https://hdl.handle.net/2440/100619
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Type: | Journal article |
Title: | The association of obstructive sleep apnea (OSA) and nocturnal hypoxemia with the development of abnormal HbA1c in a population cohort of men without diabetes |
Author: | Appleton, S.L. Vakulin, A. Wittert, G.A. Martin, S.A. Grant, J.F. Taylor, A.W. McEvoy, R.D. Antic, N.A. Catcheside, P.G. Adams, R.J. |
Citation: | Diabetes Research and Clinical Practice, 2016; 114:151-159 |
Publisher: | Elsevier |
Issue Date: | 2016 |
ISSN: | 0168-8227 1872-8227 |
Abstract: | <h4>Aim</h4>To examine the relationship between indices of undiagnosed OSA and the development of abnormal glycaemic control in community-dwelling men free of diabetes.<h4>Methods</h4>The Men, Androgens, Inflammation, Lifestyle, Environment, and Stress (MAILES) Study is a population-based cohort study in Adelaide, South Australia. Clinic visits at baseline (2002-06) and follow-up (2007-10) identified abnormal glycaemic metabolism [HbA1c 6.0 to <6.5% (42 to <48mmol/mol)] in men without diabetes. At follow-up (2010-11), n=837 underwent assessment of OSA by full in-home unattended polysomnography (Embletta X100).<h4>Results</h4>Development of abnormal glycaemic metabolism over 4-6 years (n=103 "incident" cases, 17.0%) showed adjusted associations [odds ratio (95% CI)] with the 1st [1.7 (0.8-3.8)], 2nd [2.4 (1.1-4.9)], and 3rd [2.3 (1.1-4.8)] quartiles of mean oxygen saturation (SaO2) compared to the highest quartile. Prevalent abnormal glycaemic metabolism (n=140, 20.8%) was independently associated with the third and fourth quartiles of percentage of sleep time with oxygen saturation <90% and lowest quartile of mean SaO2. Linear regression analysis showed a significant reduction in HbA1c [unstandardized B, 95% CI: -0.02 (-0.04, -0.002), p=0.034] per percentage point increase in mean SaO2. OSA as measured by the apnea-hypopnea index showed no adjusted relationship with abnormal glycaemic metabolism.<h4>Conclusions</h4>Development of abnormal glycaemic metabolism was associated with nocturnal hypoxemia. Improved management of OSA and glycaemic control may occur if patients presenting with one abnormality are assessed for the other. |
Keywords: | Humans Sleep Apnea, Obstructive Diabetes Mellitus Blood Glucose Polysomnography Prevalence Odds Ratio Longitudinal Studies Cross-Sectional Studies Life Style Aged Middle Aged Australia Male Hypoxia Glycated Hemoglobin |
DOI: | 10.1016/j.diabres.2015.12.007 |
Published version: | http://dx.doi.org/10.1016/j.diabres.2015.12.007 |
Appears in Collections: | Aurora harvest 7 Medicine publications |
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