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Type: Journal article
Title: Molecular imaging needles: dual-modality optical coherence tomography and fluorescence imaging of labeled antibodies deep in tissue
Author: Scolaro, L.
Lorenser, D.
Madore, W.
Kirk, R.
Kramer, A.
Yeoh, G.
Godbout, N.
Sampson, D.
Boudoux, C.
McLaughlin, R.
Citation: Biomedical Optics Express, 2015; 6(5):1767-1781
Publisher: Optical Society of America
Issue Date: 2015
ISSN: 2156-7085
Statement of
Loretta Scolaro, Dirk Lorenser, Wendy-Julie Madore, Rodney W. Kirk, Anne S. Kramer, George C. Yeoh, Nicolas Godbout, David D. Sampson, Caroline Boudoux, and Robert A. McLaughlin
Abstract: Molecular imaging using optical techniques provides insight into disease at the cellular level. In this paper, we report on a novel dualmodality probe capable of performing molecular imaging by combining simultaneous three-dimensional optical coherence tomography (OCT) and two-dimensional fluorescence imaging in a hypodermic needle. The probe, referred to as a molecular imaging (MI) needle, may be inserted tens of millimeters into tissue. The MI needle utilizes double-clad fiber to carry both imaging modalities, and is interfaced to a 1310-nm OCT system and a fluorescence imaging subsystem using an asymmetrical double-clad fiber coupler customized to achieve high fluorescence collection efficiency. We present, to the best of our knowledge, the first dual-modality OCT and fluorescence needle probe with sufficient sensitivity to image fluorescently labeled antibodies. Such probes enable high-resolution molecular imaging deep within tissue.
Keywords: (110.2350) Fiber optics imaging
(170.0180) Microscopy
(170.2520) Fluorescence microscopy
(170.4500) Optical coherence tomography
Rights: ©2015 Optical Society of America. Open Access
DOI: 10.1364/BOE.6.001767
Grant ID: ARC
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