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dc.contributor.authorFindlay, D.-
dc.contributor.authorKuliwaba, J.-
dc.identifier.citationBone Research, 2016; 4(1):1-12-
dc.description.abstractAlthough cartilage degradation is the characteristic feature of osteoarthritis (OA), it is now recognized that the whole joint is involved in the progression of OA. In particular, the interaction (crosstalk) between cartilage and subchondral bone is thought to be a central feature of this process. The interface between articular cartilage and bone of articulating long bones is a unique zone, which comprises articular cartilage, below which is the calcified cartilage sitting on and intercalated into the subchondral bone plate. Below the subchondral plate is the trabecular bone at the end of the respective long bones. In OA, there are well-described progressive destructive changes in the articular cartilage, which parallel characteristic changes in the underlying bone. This review examines the evidence that biochemical and biomechanical signaling between these tissue compartments is important in OA disease progression and asks whether such signaling might provide possibilities for therapeutic intervention to halt or slow disease development.-
dc.description.statementofresponsibilityDavid M Findlay and Julia S Kuliwaba-
dc.publisherNature Publishing Group-
dc.rights© The Author(s) 2016. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons. org/licenses/by/4.0/-
dc.titleBone-cartilage crosstalk: a conversation for understanding osteoarthritis-
dc.typeJournal article-
dc.identifier.orcidKuliwaba, J. [0000-0003-1942-9299]-
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