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https://hdl.handle.net/2440/103232
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Type: | Journal article |
Title: | Fetal fibronectin status and cervical length in women with threatened preterm labor and the effectiveness of maintenance tocolysis |
Author: | Roos, C. Vis, J. Scheepers, H. Bloemenkamp, K. Duvekot, H. Van Eyck, J. De Groot, C. Kok, J. Opmeer, B. Oudijk, M. Papatsonis, D. Porath, M. Sollie, K. Spaanderman, M. Lotgering, F. Van Der Post, J. Mol, B. |
Citation: | The Journal of Maternal-Fetal and Neonatal Medicine, 2016; 29(10):1556-1561 |
Publisher: | Taylor & Francis |
Issue Date: | 2016 |
ISSN: | 1476-7058 1476-4954 |
Statement of Responsibility: | Carolien Roos, Jolande Y. Vis, Hubertina C.J. Scheepers, Kitty W.M. Bloemenkamp, Hans J.J. Duvekot, Jim van Eyck, Christianne de Groot, Joke H. Kok, Brent C. Opmeer, Martijn A. Oudijk, Dimitri N.M. Papatsonis, Martina M. Porath, Krystyna Sollie, Marc E.A. Spaanderman, Fred K. Lotgering, Joris A.M. van der Post, and Ben Willem J. Mol |
Abstract: | Objective: To assess the effect of maintenance tocolysis in women who are at high or low risk for preterm delivery according to fetal fibronectin (fFN) status and cervical length (CL). Study Design: We compared the risk of preterm delivery in fFN pos and fFN neg women and in women with a CL <15 mm and ≥15 mm, by using the Cox regression. Differences between the effectiveness of maintenance tocolysis in high- and low-risk women were assessed by using an interaction term. Results: 122 fFN tests were taken, of which 50 were fFN pos. CL was measured in 236 women, of whom 52 women had a CL <15 mm. The median gestational age at delivery was lower in fFN pos women; fFN pos women had a higher hazard for preterm delivery at any point of time (HR 4.7; 95% CI 2.9 to 7.6). Comparable results were seen for CL. Neither fFN status nor CL did alter the effect of maintenance tocolysis, which was ineffective in the total randomized group, on the risk of preterm delivery (p for interaction = 0.87 for fFN and 0.18 for CL). Conclusion: Maintenance tocolytic therapy with nifedipine is ineffective and not dependent on fFN or CL status. |
Keywords: | Cervical length; fetal fibronectin; maintenance tocolysis |
Rights: | © 2015 Informa UK Ltd. |
DOI: | 10.3109/14767058.2015.1053863 |
Published version: | http://dx.doi.org/10.3109/14767058.2015.1053863 |
Appears in Collections: | Aurora harvest 7 Obstetrics and Gynaecology publications |
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