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https://hdl.handle.net/2440/103521
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Type: | Journal article |
Title: | Residential location and kidney transplant outcomes in indigenous compared with nonindigenous Australians |
Author: | Barraclough, K. Grace, B. Lawton, P. McDonald, S. |
Citation: | Transplantation, 2016; 100(10):2168-2176 |
Publisher: | Wiley-Blackwell |
Issue Date: | 2016 |
ISSN: | 0041-1337 1534-6080 |
Statement of Responsibility: | Katherine A. Barraclough, Blair S. Grace, Paul Lawton, and Stephen P. McDonald |
Abstract: | Background. Indigenous Australians experience significantly worse graft and patient outcomes after kidney transplantation compared with nonindigenous Australians. It is unclear whether rural versus urban residential location might contribute to this. Methods. All adult patients from the Australia and New Zealand Dialysis and Transplant Registry who received a kidney transplant in Australia between January 1, 2000, and December 31, 2012, were investigated. Patients' residential location was classified as urban (major city + inner regional) or rural (outer regional - very remote) using the Australian Bureau of Statistics Remoteness Area Classification. Results. Of 7826 kidney transplant recipients, 271 (3%) were indigenous. Sixty-three percent of indigenous Australians lived in rural locations compared with 10% of nonindigenous Australians (P < 0.001). In adjusted analyses, the hazards ratio for graft loss for Indigenous compared with non-Indigenous race was 1.59 (95% confidence interval [95% CI], 1.01-2.50; P = 0.046). Residential location was not associated with graft survival. Both indigenous race and residential location influenced patient survival, with an adjusted hazards ratio for death of 1.94 (95% CI, 1.23-3.05; P = 0.004) comparing indigenous with nonindigenous and 1.26 (95% CI, 1.01-1.58; P = 0.043) comparing rural with urban recipients. Five-year graft and patient survivals were 70% (95% CI, 60%-78%) and 69% (95% CI, 61%-76%) in rural indigenous recipients compared with 91% (95% CI, 90%-92%) and 92% (95% CI, 91%-93%) in urban nonindigenous recipients. Conclusions. Indigenous kidney transplant recipients experience worse patient and graft survival compared with nonindigenous recipients, whereas rural residential location is associated with patient but not graft survival. Of all groups, indigenous recipients residing in rural locations experienced the lowest 5-year graft and patient survivals. |
Keywords: | Humans Creatinine Kidney Transplantation Graft Rejection Graft Survival Adolescent Adult Middle Aged Female Male Delayed Graft Function Native Hawaiian or Other Pacific Islander |
Rights: | Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. |
DOI: | 10.1097/TP.0000000000001007 |
Published version: | http://dx.doi.org/10.1097/tp.0000000000001007 |
Appears in Collections: | Aurora harvest 7 Medicine publications |
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