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Type: Theses
Title: Does transgenic feed cause histopathological changes in rats?
Author: Zdziarski, Irena Maria
Issue Date: 2016
School/Discipline: School of Medical Sciences
Abstract: Genetically modified (GM) crops have been commercially available for human and animal consumption since the 1990s. The safety evaluations are based on the concept of substantial equivalence, which assumes that the toxicity of a product can be investigated by assessing the toxicity of individual components of the product and not the product as a whole. In other words, the test for substantial equivalence does not require animal feeding trials unless one or more of the individual components of the crop indicates a need. Such an approach does not take into account the changes, which may have arisen during, or following, the production of the GM crop. Furthermore, the few animal feeding studies that have been performed very rarely report results of any morphometric histological analyses. The present study, aimed to investigate the effects of feeding a GM-corn diet to rats at two doses (60% and 30%) by studying the morphological features of the mucosa of the stomach and small intestine, both at light and electron microscopic levels. The morphological features were quantified using morphometric methods. In addition, tight junction proteins were investigated using immunohistochemistry and immunofluorescence confocal microscopy. Both studies (60% and 30% of corn in the diet) showed changes in morphology and cell-counts that indicate that GM crops may have an effect on rat health. These findings support the importance of animal feeding studies and the need for morphometric analyses to evaluate the safety of GM-feed consumption on animal health.
Advisor: Kumaratilake, Jaliya
Haynes, Julie Irene
Edwards, John
Gibson, Rachel Jane
Dissertation Note: Thesis (Ph.D.) -- University of Adelaide, Adelaide Medical School, 2016.
Keywords: genetically modified crop
rat feeding study
long-term feeding study
gastrointestinal tract
Provenance: This electronic version is made publicly available by the University of Adelaide in accordance with its open access policy for student theses. Copyright in this thesis remains with the author. This thesis may incorporate third party material which has been used by the author pursuant to Fair Dealing exceptions. If you are the owner of any included third party copyright material you wish to be removed from this electronic version, please complete the take down form located at:
DOI: 10.4225/55/58b79cfc61fd2
Appears in Collections:Research Theses

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