Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/103585
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Type: Journal article
Title: Acute effects of the glucagon-like peptide-1 receptor agonist, exenatide, on blood pressure and heart rate responses to intraduodenal glucose infusion in type 2 diabetes
Author: Thazhath, S.
Marathe, C.
Wu, T.
Chang, J.
Khoo, J.
Kuo, P.
Checklin, H.
Bound, M.
Rigda, R.
Horowitz, M.
Jones, K.
Rayner, C.
Citation: Diabetes and Vascular Disease Research, 2017; 14(1):59-63
Publisher: Sage Publication Ltd
Issue Date: 2017
ISSN: 1479-1641
1752-8984
Statement of
Responsibility: 
Sony S Thazhath, Chinmay S Marathe, Tongzhi Wu, Jessica Chang, Joan Khoo, Paul Kuo, Helen L Checklin, Michelle J Bound, Rachael S Rigda, Michael Horowitz, Karen L Jones, and Christopher K Rayner
Abstract: Aim: To evaluate the effects of the glucagon-like peptide-1 receptor agonist, exenatide, on blood pressure and heart rate during an intraduodenal glucose infusion in type 2 diabetes. Methods: Nine subjects with type 2 diabetes were randomised to receive intravenous exenatide or saline control in a crossover design. Glucose (3 kcal min−1) was infused via an intraduodenal manometry catheter for 60 min. Blood pressure, heart rate, and the frequency and amplitude of duodenal pressure waves were measured at regular intervals. Gastrointestinal symptoms were monitored using 100 mm visual analogue scales. Results: During intraduodenal glucose infusion (0–60 min), diastolic (p(0–60) = 0.03) and mean arterial (p(0–60) = 0.03) blood pressures and heart rate (p(0–60) = 0.06; p(0–120) = 0.03)) were higher with exenatide compared to placebo. The increase in the area under the curve for diastolic blood pressure and mean arterial blood pressure was related directly to the suppression of the duodenal motility index with exenatide compared to control (p = 0.007 and 0.04, respectively). Conclusion: In type 2 diabetes, intravenous exenatide increases mean arterial blood pressure and heart rate during an intraduodenal glucose infusion, supporting the need for further research with exenatide for its potential use in postprandial hypotension.
Keywords: Glucagon-like peptide-1 receptor agonist; exenatide; ‘gut–heart axis'; postprandial hypotension
Rights: © The Author(s) 2016
RMID: 0030059550
DOI: 10.1177/1479164116666761
Appears in Collections:Medicine publications

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