Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/103704
Citations
Scopus Web of Science® Altmetric
?
?
Full metadata record
DC FieldValueLanguage
dc.contributor.authorPerez-Andreu, V.en
dc.contributor.authorRoberts, K.en
dc.contributor.authorHarvey, R.en
dc.contributor.authorYang, W.en
dc.contributor.authorCheng, C.en
dc.contributor.authorPei, D.en
dc.contributor.authorXu, H.en
dc.contributor.authorGastier-Foster, J.en
dc.contributor.authorE, S.en
dc.contributor.authorLim, J.en
dc.contributor.authorChen, I.en
dc.contributor.authorFan, Y.en
dc.contributor.authorDevidas, M.en
dc.contributor.authorBorowitz, M.en
dc.contributor.authorSmith, C.en
dc.contributor.authorNeale, G.en
dc.contributor.authorBurchard, E.en
dc.contributor.authorTorgerson, D.en
dc.contributor.authorAntillon Klussmann, F.en
dc.contributor.authorNajera Villagran, C.en
dc.contributor.authoret al.en
dc.date.issued2013en
dc.identifier.citationNature Genetics, 2013; 45(12):1494-1498en
dc.identifier.issn1061-4036en
dc.identifier.issn1546-1718en
dc.identifier.urihttp://hdl.handle.net/2440/103704-
dc.description.abstractRecent genomic profiling of childhood acute lymphoblastic leukemia (ALL) identified a high-risk subtype with an expression signature resembling that of Philadelphia chromosome-positive ALL and poor prognosis (Ph-like ALL). However, the role of inherited genetic variation in Ph-like ALL pathogenesis remains unknown. In a genome-wide association study (GWAS) of 511 ALL cases and 6,661 non-ALL controls, we identified a susceptibility locus for Ph-like ALL (GATA3, rs3824662; P = 2.17 × 10⁻¹⁴, odds ratio (OR) = 3.85 for Ph-like ALL versus non-ALL; P = 1.05 × 10(-8), OR = 3.25 for Ph-like ALL versus non-Ph-like ALL), with independent validation. The rs3824662 risk allele was associated with somatic lesions underlying Ph-like ALL (CRLF2 rearrangement, JAK gene mutation and IKZF1 deletion) and with variation in GATA3 expression. Finally, genotype at the GATA3 SNP was also associated with early treatment response and risk of ALL relapse. Our results provide insights into interactions between inherited and somatic variants and their role in ALL pathogenesis and prognosis.en
dc.description.statementofresponsibilityVirginia Perez-Andreu, Kathryn G Roberts, Richard C Harvey, Wenjian Yang, Cheng Cheng, Deqing Pei, Heng Xu, Julie Gastier-Foster, Shuyu E, Joshua Yew-Suang Lim, I-Ming Chen, Yiping Fan, Meenakshi Devidas, Michael J Borowitz, Colton Smith, Geoffrey Neale, Esteban G Burchard, Dara G Torgerson, Federico Antillon Klussmann, Cesar Rolando Najera Villagran, Naomi J Winick, Bruce M Camitta, Elizabeth Raetz, Brent Wood, Feng Yue, William L Carroll, Eric Larsen, W Paul Bowman, Mignon L Loh, Michael Dean, Deepa Bhojwani, Ching-Hon Pui, William E Evans, Mary V Relling, Stephen P Hunger, Cheryl L Willman, Charles G Mullighan, Jun J Yanen
dc.language.isoenen
dc.publisherNature Publishing Groupen
dc.rights© 2013 Nature America, Inc. All rights reserved.en
dc.subjectGATA3 transcription factoren
dc.titleInherited GATA3 variants are associated with Ph-like childhood acute lymphoblastic leukemia and risk of relapseen
dc.typeJournal articleen
dc.identifier.rmid0030061212en
dc.identifier.doi10.1038/ng.2803en
dc.identifier.pubid277149-
pubs.library.collectionMedicine publicationsen
pubs.library.teamDS14en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidMullighan, C. [0000-0002-1871-1850]en
Appears in Collections:Medicine publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.