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https://hdl.handle.net/2440/103911
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dc.contributor.author | Appleton, S.L. | - |
dc.contributor.author | Vakulin, A. | - |
dc.contributor.author | Martin, S.A. | - |
dc.contributor.author | Lang, C.J. | - |
dc.contributor.author | Wittert, G.A. | - |
dc.contributor.author | Taylor, A.W. | - |
dc.contributor.author | McEvoy, R.D. | - |
dc.contributor.author | Antic, N.A. | - |
dc.contributor.author | Catcheside, P.G. | - |
dc.contributor.author | Adams, R.J. | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Chest, 2016; 150(3):495-505 | - |
dc.identifier.issn | 0012-3692 | - |
dc.identifier.issn | 1931-3543 | - |
dc.identifier.uri | http://hdl.handle.net/2440/103911 | - |
dc.description.abstract | BACKGROUND: Evidence linking OSA with hypertension in population studies is conflicting. We examined longitudinal and cross-sectional associations of previously unrecognized OSA, including OSA occurring in rapid eye movement (REM) sleep, with hypertension. METHODS: The Men Androgens Inflammation Lifestyle Environment and Stress (MAILES) study is a longitudinal study of community-dwelling men in Adelaide, South Australia. Biomedical assessments at baseline (2002-2006) and follow-up (2007-2010) identified hypertension (systolic $ 140 mm Hg and/or diastolic $ 90 mm Hg, or medication) and risk factors. In 2010 to 2011, 837 men without a prior diagnosis of OSA underwent full in-home unattended polysomnography of whom 739 recorded $ 30 min of REM sleep. Hypertension at follow-up (concomitant with OSA status) was defined as prevalent hypertension. Recentonset hypertension was defined as hypertension at biomedical follow-up (56 months mean follow-up [range, 48-74]) in men free of hypertension at baseline. RESULTS: Severe REM OSA (apnea hypopnea index $30/h) showed independent adjusted associations with prevalent (OR, 2.40, 95% CI, 1.42-4.06), and recent-onset hypertension (2.24 [1.04-4.81]). Significant associations with non-REM AHI were not seen. In men with AHI < 10, REM OSA (apnea hypopnea index) $ 20/h was significantly associated with prevalent hypertension (2.67 [1.33-5.38]) and the relationship with recent-onset hypertension was positive but not statistically significant (2.32 [0.79-6.84]). Similar results were seen when analyses were confined to men with non-REM AHI < 10. CONCLUSIONS: In men not considered to have OSA (AHI < 10), hypertension was associated with OSA during REM sleep. REM OSA may need consideration as an important clinical entity requiring treatment but further systematic assessment and evidence is needed. | - |
dc.description.statementofresponsibility | Sarah L. Appleton, Andrew Vakulin, Sean A. Martin, Carol J. Lang, Gary A. Wittert, Anne W. Taylor, R. Doug McEvoy, Nick A. Antic, Peter G. Catcheside and Robert J. Adams | - |
dc.language.iso | en | - |
dc.publisher | American College of Chest Physicians | - |
dc.rights | Copyright © 2016 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1016/j.chest.2016.03.010 | - |
dc.subject | Epidemiology; hypertension; men; obstructive sleep apnea; rapid eye movement sleep | - |
dc.title | Hypertension is associated with undiagnosed OSA during rapid eye movement sleep | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.chest.2016.03.010 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/627227 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Appleton, S.L. [0000-0001-7292-9714] | - |
dc.identifier.orcid | Lang, C.J. [0000-0002-3832-6984] | - |
dc.identifier.orcid | Wittert, G.A. [0000-0001-6818-6065] | - |
dc.identifier.orcid | Taylor, A.W. [0000-0002-4422-7974] | - |
dc.identifier.orcid | McEvoy, R.D. [0000-0002-5759-0094] | - |
dc.identifier.orcid | Catcheside, P.G. [0000-0002-9372-6788] | - |
dc.identifier.orcid | Adams, R.J. [0000-0002-7572-0796] | - |
Appears in Collections: | Aurora harvest 7 Medicine publications |
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