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Type: Journal article
Title: The mediterranean diet and cognitive function among healthy older adults in a 6-month randomised controlled trial: the MedLey study
Author: Knight, A.
Bryan, J.
Wilson, C.
Hodgson, J.M.
Davis, C.R.
Murphy, K.J.
Citation: Nutrients, 2016; 8(9):579-1-579-17
Publisher: MDPI AG
Issue Date: 2016
ISSN: 2072-6643
Statement of
Alissa Knight, Janet Bryan, Carlene Wilson, Jonathan M. Hodgson, Courtney R. Davis and Karen J. Murphy
Abstract: Evidence from a limited number of randomised controlled intervention trials (RCTs) have shown that a Mediterranean dietary pattern may reduce the risk of cognitive decline and enhance cognitive function among healthy older adults. However, there are currently no data in non-Mediterranean older adult populations. The present study aimed to address this gap by examining the effect of a Mediterranean dietary pattern (MedDiet) for six months on aspects of cognitive function in a randomised controlled intervention trial (the MedLey study) that extended for a duration of 18 months. In the final analysed cohort, a total of 137 men and women (mean age of 72.1 ± 5.0 years) randomly assigned to either a MedDiet or control diet (HabDiet) (i.e., habitual dietary intake), were assessed on a comprehensive neuropsychological test battery, including 11 individual tests. In multivariable-adjusted models, the MedDiet group did not perform significantly better than the HabDiet control group for executive functioning (adjusted mean differences: +2.53, 95% CI −2.59 to 7.65, p = 0.33); speed of processing (adjusted mean differences: +3.24, 95% CI −1.21 to 7.70, p = 0.15); memory (adjusted mean differences: +2.00, 95% CI −3.88 to 7.88, p = 0.50); visual-spatial ability (adjusted mean differences: +0.21, 95% CI −0.38 to 0.81, 0.48); and overall age-related cognitive performance (adjusted mean differences: +7.99, 95% CI −4.00 to 19.9, p = 0.19). In conclusion, this study did not find evidence of a beneficial effect of a MedDiet intervention on cognitive function among healthy older adults.
Keywords: Mediterranean diet; cognitive function; randomised controlled trial; older adults
Rights: © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (
DOI: 10.3390/nu8090579
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