Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/104042
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Type: Journal article
Title: Occult upper gastrointestinal mucosal abnormalities in critically ill patients
Author: Ovenden, C.
Plummer, M.
Selvanderan, S.
Donaldson, T.
Nguyen, N.
Weinel, L.
Finnis, M.
Summers, M.
Ali Abdelhamid, Y.
Chapman, M.
Rayner, C.
Deane, A.
Citation: Acta Anaesthesiologica Scandinavica: an international journal of anaesthesiology and intensive care, pain and emergency medicine, 2017; 61(2):216-223
Publisher: Wiley
Issue Date: 2017
ISSN: 0001-5172
1399-6576
Statement of
Responsibility: 
C. Ovenden, M.P. Plummer, S. Selvanderan, T.A. Donaldson, N.Q. Nguyen, L.M. Weinel, M.E. Finnis, M.J. Summers, Y. Ali Abdelhamid, M.J. Chapman, C.K. Rayner and A.M. Deane
Abstract: Background: The objectives of this study were to estimate the frequency of occult upper gastrointestinal abnormalities, presence of gastric acid as a contributing factor, and associations with clinical outcomes. Methods: Data were extracted for study participants at a single centre who had an endoscopy performed purely for research purposes and in whom treating physicians were not suspecting gastrointestinal bleeding. Endoscopic data were independently adjudicated by two gastroenterologists who rated the likelihood that observed pathological abnormalities were related to gastric acid secretion using a 3-point ordinal scale (unlikely, possible or probable). Results: Endoscopy reports were extracted for 74 patients [age 52 (37, 65) years] undergoing endoscopy on day 5 [3, 9] of ICU admission. Abnormalities were found in 25 (34%) subjects: gastritis/erosions in 10 (14%), nasogastric tube trauma in 8 (11%), oesophagitis in 4 (5%) and non-bleeding duodenal ulceration in 3 (4%). The contribution of acid secretion to observed pathology was rated 'probable' in six subjects (rater #1) and five subjects (rater #2). Prior to endoscopy, 39 (53%) patients were receiving acid-suppressive therapy. The use of acid-suppressive therapy was not associated with the presence of an endoscopic abnormality (present 15/25 (60%) vs. absent 24/49 (49%); P = 0.46). Haemoglobin concentrations, packed red cells transfused and mortality were not associated with mucosal abnormalities (P = 0.83, P > 0.9 and P > 0.9 respectively). Conclusions: Occult mucosal abnormalities were observed in one-third of subjects. The presence of mucosal abnormalities appeared to be independent of prior acid-suppressive therapy and was not associated with reduced haemoglobin concentrations, increased transfusion requirements, or mortality.
Keywords: Intestinal Mucosa
Humans
Esophagitis
Gastritis
Critical Illness
Endoscopy, Gastrointestinal
Adult
Aged
Middle Aged
Intensive Care Units
Female
Male
Proton Pump Inhibitors
Rights: © 2016 The Acta Anaesthesiologica Scandinavica Foundation. Published by John Wiley & Sons Ltd
DOI: 10.1111/aas.12844
Grant ID: NHMRC
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