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Type: Journal article
Title: Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas
Author: Wu, G.
Broniscer, A.
McEachron, T.
Lu, C.
Paugh, B.
Becksfort, J.
Qu, C.
Ding, L.
Huether, R.
Parker, M.
Zhang, J.
Gajjar, A.
Dyer, M.
Mullighan, C.
Gilbertson, R.
Mardis, E.
Wilson, R.
Downing, J.
Ellison, D.
Zhang, J.
et al.
Citation: Nature Genetics, 2012; 44(3):251-253
Publisher: Nature Publishing Group
Issue Date: 2012
ISSN: 1061-4036
Statement of
Gang Wu, Alberto Broniscer, Troy A McEachron, Charles Lu, Barbara S Paugh, Jared Becksfort, Chunxu Qu, Li Ding, Robert Huether, Matthew Parker, Junyuan Zhang, Amar Gajjar, Michael A Dyer, Charles G Mullighan, Richard J Gilbertson, Elaine R Mardis, Richard K Wilson, James R Downing, David W Ellison, Jinghui Zhang and Suzanne J Baker
Abstract: To identify somatic mutations in pediatric diffuse intrinsic pontine glioma (DIPG), we performed whole-genome sequencing of DNA from seven DIPGs and matched germline tissue and targeted sequencing of an additional 43 DIPGs and 36 non-brainstem pediatric glioblastomas (non-BS-PGs). We found that 78% of DIPGs and 22% of non-BS-PGs contained a mutation in H3F3A, encoding histone H3.3, or in the related HIST1H3B, encoding histone H3.1, that caused a p.Lys27Met amino acid substitution in each protein. An additional 14% of non-BS-PGs had somatic mutations in H3F3A causing a p.Gly34Arg alteration.
Keywords: Brain Stem Neoplasms
Rights: © 2012 Nature America, Inc. All rights reserved.
DOI: 10.1038/ng.1102
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