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Type: Journal article
Title: Effects of vildagliptin and metformin on blood pressure and heart rate responses to small intestinal glucose in type 2 diabetes.
Author: Wu, T.
Trahair, L.
Little, T.
Bound, M.
Zhang, X.
Wu, H.
Sun, Z.
Horowitz, M.
Rayner, C.
Jones, K.
Citation: Diabetes Care, 2017; 40(5):702-705
Publisher: American Diabetes Association
Issue Date: 2017
ISSN: 0149-5992
Statement of
Tongzhi Wu, Laurence G. Trahair, Tanya J. Little, Michelle J. Bound, Xiang Zhang, Hang Wu, Zilin Sun, Michael Horowitz, Christopher K. Rayner and Karen L. Jones
Abstract: OBJECTIVE: To evaluate effects of vildagliptin and metformin on blood pressure (BP) and heart rate (HR) responses to intraduodenal (ID) glucose in diet-controlled type 2 diabetes. RESEARCH DESIGN AND METHODS: Study A compared vildagliptin (50 mg) and placebo, given 60 min before a 120-min ID glucose infusion at 2 or 4 kcal/min (ID2 or ID4) in 16 patients. Study B compared metformin (850 mg) and placebo, given 30 min before ID2 over 120 min in 9 patients. RESULTS: Systolic (P = 0.002) and diastolic (P < 0.001) BP were lower and HR greater (P = 0.005) after vildagliptin compared with placebo, without interaction between vildagliptin and the glucose infusion rate. In contrast, HR was greater after metformin than placebo (P < 0.001), without any difference in systolic or diastolic BP. CONCLUSIONS: Vildagliptin reduces BP and increases HR, whereas metformin increases HR without affecting BP during ID glucose infusion in type 2 diabetes. These distinct cardiovascular profiles during enteral nutrient exposure may have implications for postprandial hypotension.
Keywords: Intestine, Small
Diabetes Mellitus, Type 2
Hypoglycemic Agents
Blood Pressure
Heart Rate
Postprandial Period
Dipeptidyl-Peptidase IV Inhibitors
Rights: © 2017 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at http://www.diabetesjournals .org/content/license.
DOI: 10.2337/dc16-2391
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