Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/104990
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: Advances in multicellular spheroids formation
Author: Cui, X.
Zhang, H.
Hartanto, Y.
Citation: Journal of the Royal Society Interface, 2017; 14(127)
Publisher: Royal Society
Issue Date: 2017
ISSN: 1742-5689
1742-5662
Statement of
Responsibility: 
X. Cui, Y. Hartanto and H. Zhang
Abstract: Three-dimensional multicellular spheroids (MCSs) have a complex architectural structure, dynamic cell–cell/cell–matrix interactions and bio-mimicking in vivo microenvironment. As a fundamental building block for tissue reconstruction, MCSs have emerged as a powerful tool to narrow down the gap between the in vitro and in vivo model. In this review paper, we discussed the structure and biology of MCSs and detailed fabricating methods. Among these methods, the approach in microfluidics with hydrogel support for MCS formation is promising because it allows essential cell–cell/cell–matrix interactions in a confined space.
Keywords: Multicellular spheroids; tissue engineering; three-dimensional culture; microfluidics; hydrogel
Rights: © 2017 The Author(s) Published by the Royal Society. All rights reserved.
DOI: 10.1098/rsif.2016.0877
Grant ID: http://purl.org/au-research/grants/arc/DP160104632
Appears in Collections:Aurora harvest 8
Chemical Engineering publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.