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Type: Journal article
Title: Advances in multicellular spheroids formation
Author: Cui, X.
Zhang, H.
Hartanto, Y.
Citation: Journal of the Royal Society Interface, 2017; 14(127)
Publisher: Royal Society
Issue Date: 2017
ISSN: 1742-5689
Statement of
X. Cui, Y. Hartanto and H. Zhang
Abstract: Three-dimensional multicellular spheroids (MCSs) have a complex architectural structure, dynamic cell–cell/cell–matrix interactions and bio-mimicking in vivo microenvironment. As a fundamental building block for tissue reconstruction, MCSs have emerged as a powerful tool to narrow down the gap between the in vitro and in vivo model. In this review paper, we discussed the structure and biology of MCSs and detailed fabricating methods. Among these methods, the approach in microfluidics with hydrogel support for MCS formation is promising because it allows essential cell–cell/cell–matrix interactions in a confined space.
Keywords: Multicellular spheroids; tissue engineering; three-dimensional culture; microfluidics; hydrogel
Rights: © 2017 The Author(s) Published by the Royal Society. All rights reserved.
DOI: 10.1098/rsif.2016.0877
Grant ID:
Appears in Collections:Aurora harvest 8
Chemical Engineering publications

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