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Type: Journal article
Title: A simple and inexpensive enteric-coated capsule for delivery of acid-labile macromolecules to the small intestine
Author: Miller, D.
Parsons, A.
Bresland, J.
Herde, P.
Pham, D.
Tan, A.
Hsu, H.-Y.
Prestidge, C.
Kuchel, T.
Begg, R.
Aziz, S.
Butler, R.
Citation: Zhejiang University Journal (Science B): international biomedicine and biotechnology journal, 2015; 16(7):586-592
Publisher: Zhejiang Daxue
Issue Date: 2015
ISSN: 1673-1581
Statement of
Darren S. Miller, Anne Michelle Parsons, John Bresland, Paul Herde, Duc Minh Pham, Angel Tan, Hung-Yao Hsu, Clive A. Prestidge, Tim Kuchel, Rezaul Begg, Syed Mahfuzul Aziz, Ross N. Butler
Abstract: Understanding the ecology of the gastrointestinal tract and the impact of the contents on the host mucosa is emerging as an important area for defining both wellness and susceptibility to disease. Targeted delivery of drugs to treat specific small intestinal disorders such as small bowel bacterial overgrowth and targeting molecules to interrogate or to deliver vaccines to the remote regions of the small intestine has proven difficult. There is an unmet need for methodologies to release probes/drugs to remote regions of the gastrointestinal tract in furthering our understanding of gut health and pathogenesis. In order to address this concern, we need to know how the regional delivery of a surrogate labeled test compound is handled and in turn, if delivered locally as a liquid or powder, the dynamics of its subsequent handling and metabolism. In the studies we report on in this paper, we chose 13C sodium acetate (13C-acetate), which is a stable isotope probe that once absorbed in the small intestine can be readily measured non-invasively by collection and analysis of 13CO2 in the breath. This would provide information of gastric emptying rates and an indication of the site of release and absorptive capacity. In a series of in vitro and in vivo pig experiments, we assessed the enteric-protective properties of a commercially available polymer EUDRAGIT® L100-55 on gelatin capsules and also on DRcaps®. Test results demonstrated that DRcaps® coated with EUDRAGIT® L100-55 possessed enhanced enteric-protective properties, particularly in vivo. These studies add to the body of knowledge regarding gastric emptying in pigs and also begin the process of gathering specifications for the design of a simple and cost-effective enteric-coated capsule for delivery of acid-labile macromolecules to the small intestine.
Keywords: Breath testing; pig; endoscopic capsule; gastric emptying; biomarker delivery; gastrointestinal tract
Rights: © Zhejiang University and Springer-Verlag Berlin Heidelberg 2015
DOI: 10.1631/jzus.B1400290
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Appears in Collections:Animal and Veterinary Sciences publications
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