Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/106517
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Type: Journal article
Title: Post-discharge electrocardiogram Holter monitoring in recently hospitalised individuals with chronic atrial fibrillation to enhance therapeutic monitoring and identify potentially predictive phenotypes
Author: Ball, J.
Carrington, M.
Thompson, D.
Horowitz, J.
Stewart, S.
Citation: European Journal of Cardiovascular Nursing, 2015; 14(5):384-394
Publisher: SAGE
Issue Date: 2015
ISSN: 1474-5151
1873-1953
Statement of
Responsibility: 
Jocasta Ball, Melinda J Carrington, David R Thompson, John D Horowitz, and Simon Stewart, on behalf of the Standard versus Atrial Fibrillation spEcific managemenT studY, SAFETY, investigators
Abstract: Atrial fibrillation (AF) is the most common cardiac arrhythmia managed in clinical practice. Maintenance of intended rate or rhythm control following hospitalisation is a key therapeutic goal.The purpose of this study was to assess post-discharge maintenance of intended AF control and classify potentially predictive heart rate (HR) phenotypes via electrocardiogram (ECG) Holter monitoring.In a sub-study of a multicentre randomised controlled trial comparing AF-specific management with usual care, 24-hour ECG Holter monitoring was undertaken in 133 patients 7-14 days post-discharge. Intended rate and rhythm control were compared to Holter data. Analysis of the frequency distribution of mean hour-to-hour differences identified those with labile HRs.Mean age was 71 ± 10 years, 67 (50%) were male and mean HR was 72 ± 14 bpm. Most (89%) had persistent AF (median time in AF=39% (IQR 0-100%)). Uncontrolled HR (>90 bpm for >10% of recording) occurred in 35 (26%) patients and 49 (37%) patients did not achieve their intended rate (n=26) or rhythm control (n=23). Patients in the upper quartile of mean hour-to-hour HR variability were identified as persistently labile (n=33). A further group (n=22) with periodically labile HRs was identified. Those with coronary artery disease (OR 0.34; 95% CI 0.13-0.91, p=0.033) or renal disease/dysfunction (OR 0.24; 95% CI 0.06-0.98, p=0.047) were less likely to demonstrate HR stability (n=78).Post-discharge ECG Holter monitoring of AF patients represents a valuable tool to identify deviations in intended rhythm/rate control and adjust therapeutic management accordingly. It may also identify individuals who demonstrate labile HRs.
Keywords: Atrial fibrillation; Holter monitoring; risk delineation; disease management
Rights: © The European Society of Cardiology 2014
RMID: 0030073004
DOI: 10.1177/1474515114547650
Grant ID: http://purl.org/au-research/grants/nhmrc/519823
Appears in Collections:Medicine publications

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