Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/106533
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Type: Journal article
Title: Absence of evidence for bornavirus infection in schizophrenia, bipolar disorder and major depressive disorder
Author: Hornig, M.
Briese, T.
Licinio, J.
Khabbaz, R.
Altshuler, L.
Potkin, S.
Schwemmle, M.
Siemetzki, U.
Mintz, J.
Honkavuori, K.
Kraemer, H.
Egan, M.
Whybrow, P.
Bunney, W.
Lipkin, W.
Citation: Molecular Psychiatry, 2012; 17(5):486-493
Publisher: Nature Publishing Group
Issue Date: 2012
ISSN: 1359-4184
1476-5578
Statement of
Responsibility: 
M. Hornig, T. Briese, J. Licinio, R. F. Khabbaz, L. L. Altshuler, S. G. Potkin, M. Schwemmle, U. Siemetzki, J. Mintz, K. Honkavuori, H. C. Kraemer, M. F. Egan, P. C. Whybrow, W. E. Bunney and W. I. Lipkin
Abstract: In 1983, reports of antibodies in subjects with major depressive disorder (MDD) to an as-yet uncharacterized infectious agent associated with meningoencephalitis in horses and sheep led to molecular cloning of the genome of a novel, negative-stranded neurotropic virus, Borna disease virus (BDV). This advance has enabled the development of new diagnostic assays, including in situ hybridization, PCR and serology based on recombinant proteins. Since these assays were first implemented in 1990, more than 80 studies have reported an association between BDV and a wide range of human illnesses that include MDD, bipolar disorder (BD), schizophrenia (SZ), anxiety disorder, chronic fatigue syndrome, multiple sclerosis, amyotrophic lateral sclerosis, dementia and glioblastoma multiforme. However, to date there has been no blinded case-control study of the epidemiology of BDV infection. Here, in a United States-based, multi-center, yoked case-control study with standardized methods for clinical assessment and blinded serological and molecular analysis, we report the absence of association of psychiatric illness with antibodies to BDV or with BDV nucleic acids in serially collected serum and white blood cell samples from 396 subjects, a study population comprised of 198 matched pairs of patients and healthy controls (52 SZ/control pairs, 66 BD/control pairs and 80 MDD/control pairs). Our results argue strongly against a role for BDV in the pathogenesis of these psychiatric disorders.
Keywords: Borna disease virus; infection; schizophrenia; affective disorders; pathogenesis
Rights: © 2012 Macmillan Publishers Limited
RMID: 0030048373
DOI: 10.1038/mp.2011.179
Appears in Collections:Medicine publications

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