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Type: Journal article
Title: Numerical and experimental investigations of the flow-pressure relation in multiple sequential stenoses coronary artery
Author: Li, S.
Chin, C.
Thondapu, V.
Poon, E.
Monty, J.
Li, Y.
Ooi, A.
Tu, S.
Barlis, P.
Citation: International Journal of Cardiovascular Imaging, 2017; 33(7):1083-1088
Publisher: Springer
Issue Date: 2017
ISSN: 1569-5794
Statement of
S. Li, Cheng Chin, Vikas Thondapu, Eric K.W. Poon, Jason P. Monty, Yingguang Li, Andrew S.H. Ooi, Shengxian Tu, Peter Barlis
Abstract: Virtual fractional flow reserve (vFFR) has been evaluated as an adjunct to invasive fractional flow reserve (FFR) in the light of its operational and economic benefits. The accuracy of vFFR and the complexity of hyperemic flow simulation are still not clearly understood. This study investigates the flow-pressure relation in an idealised multiple sequential stenoses coronary artery model via numerical and experimental approaches. Pressure drop is linearly correlated with flow rate irrespective of the number of stenosis. Computational fluid dynamics results are in good agreement with the experimental data, demonstrating reasonable accuracy of vFFR. It was also found that the difference between data obtained with steady and pulsatile flows is negligible, indicating the steady flow may be used instead of pulsatile flow conditions in vFFR computation. This study adds to the current understanding of vFFR and may improve its clinical applicability as an adjunct to invasively determined FFR.
Keywords: Computational fluid dynamics
Flow–pressure relation
Fractional flow reserve
Rights: © The Author(s) 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
DOI: 10.1007/s10554-017-1093-3
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