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Type: Journal article
Title: An adenoviral vector based vaccine for Rhodococcus equi
Author: Giles, C.
Ndi, O.
Barton, M.
Vanniasinkam, T.
Citation: PLoS One, 2016; 11(3):1-15
Publisher: PloS One
Issue Date: 2016
ISSN: 1932-6203
Editor: Butaye, P.
Statement of
Carla Giles, Olasumbo Ndi, Mary D. Barton, Thiru Vanniasinkam
Abstract: Rhodococcus equi is a respiratory pathogen which primarily infects foals and is endemic on farms around the world with 50% mortality and 80% morbidity in affected foals. Unless detected early and treated appropriately the disease can be fatal. Currently, there is no vaccine available to prevent this disease. For decades researchers have endeavoured to develop an effective vaccine to no avail. In this study a novel human adenoviral vector vaccine for R. equi was developed and tested in the mouse model. This vaccine generated a strong antibody and cytokine response and clearance of R. equi was demonstrated following challenge. These results show that this vaccine could potentially be developed further for use as a vaccine to prevent R. equi disease in foals.
Keywords: Lung
Mice, Inbred C3H
Rhodococcus equi
Actinomycetales Infections
Horse Diseases
Bacterial Vaccines
Antibodies, Bacterial
Enzyme-Linked Immunosorbent Assay
Rights: © 2016 Giles et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
DOI: 10.1371/journal.pone.0152149
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Zoology publications

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