Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/109663
Citations
Scopus Web of Science® Altmetric
?
?
Full metadata record
DC FieldValueLanguage
dc.contributor.authorGueugnon, F.en
dc.contributor.authorDenis, I.en
dc.contributor.authorPouliquen, D.en
dc.contributor.authorCollette, F.en
dc.contributor.authorDelatouche, R.en
dc.contributor.authorHéroguez, V.en
dc.contributor.authorGrégoire, M.en
dc.contributor.authorBertrand, P.en
dc.contributor.authorBlanquart, C.en
dc.date.issued2013en
dc.identifier.citationBiomacromolecules, 2013; 14(7):2396-2402en
dc.identifier.issn1525-7797en
dc.identifier.issn1526-4602en
dc.identifier.urihttp://hdl.handle.net/2440/109663-
dc.description.abstractWe described a norbornenyl-poly(ethylene oxide) nanoparticles ligand-free generic platform, made fluorescent with straightforward preparation by ring-opening metathesis polymerization (ROMP). Our method allowed to easily obtain a drug delivery system (DDS) with facilitated functionalization by means of azide−alkyne click chemistry and with a high selectivity for the tumor in vivo, while cellular internalization is obtained without cell targeting strategy. We demonstrated that our nanoparticles are internalized by endocytosis and colocalized with acidic intracellular compartments in two models of aggressive tumoral cell lines with low prognostic and limited therapeutic treatments. Our nanoparticles could be of real interest to limit the toxicity and to increase the clinical benefit of drugs suffering rapid clearance and side effects and an alternative for cancers with poorly efficient therapeutic solutions by associating the drug delivery in the tumor tissue with an acid-sensitive release system.en
dc.description.statementofresponsibilityFabien Gueugnon, Iza Denis, Daniel Pouliquen, Floraine Collette, Régis Delatouche, Valérie Héroguez, Marc Grégoire, Philippe Bertrand and Christophe Blanquarten
dc.language.isoenen
dc.publisherAmerican Chemical Societyen
dc.rights© 2013 American Chemical Societyen
dc.titleNanoparticles produced by ring-opening metathesis polymerization using norbornenyl-poly(ethylene oxide) as a ligand-free generic platform for highly selective in vivo tumor targetingen
dc.typeJournal articleen
dc.identifier.rmid0030066010en
dc.identifier.doi10.1021/bm400516ben
dc.identifier.pubid292967-
pubs.library.collectionMedicine publicationsen
pubs.library.teamDS14en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidDenis, I. [0000-0002-2882-4306]en
Appears in Collections:Medicine publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.