Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/112456
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Type: | Journal article |
Title: | Real time classification of viruses in 12 dimensions |
Author: | Yu, C. Hernandez, T. Zheng, H. Yau, S.-C. Huang, H.-H. He, R. Yang, J. Yau, S.-T. |
Citation: | PLoS One, 2013; 8(5):e64328-1-e64328-10 |
Publisher: | Public Library of Science |
Issue Date: | 2013 |
ISSN: | 1932-6203 1932-6203 |
Editor: | Martin, D. |
Statement of Responsibility: | Chenglong Yu, Troy Hernandez, Hui Zheng, Shek-Chung Yau, Hsin-Hsiung Huang, Rong Lucy He, Jie Yang, Stephen S.-T. Yau |
Abstract: | The International Committee on Taxonomy of Viruses authorizes and organizes the taxonomic classification of viruses. Thus far, the detailed classifications for all viruses are neither complete nor free from dispute. For example, the current missing label rates in GenBank are 12.1% for family label and 30.0% for genus label. Using the proposed Natural Vector representation, all 2,044 single-segment referenced viral genomes in GenBank can be embedded in R¹². Unlike other approaches, this allows us to determine phylogenetic relations for all viruses at any level (e.g., Baltimore class, family, subfamily, genus, and species) in real time. Additionally, the proposed graphical representation for virus phylogeny provides a visualization of the distribution of viruses in R¹². Unlike the commonly used tree visualization methods which suffer from uniqueness and existence problems, our representation always exists and is unique. This approach is successfully used to predict and correct viral classification information, as well as to identify viral origins; e.g. a recent public health threat, the West Nile virus, is closer to the Japanese encephalitis antigenic complex based on our visualization. Based on crossvalidation results, the accuracy rates of our predictions are as high as 98.2% for Baltimore class labels, 96.6% for family labels, 99.7% for subfamily labels and 97.2% for genus labels. |
Keywords: | Viruses Phylogeny Genes, Viral |
Rights: | © 2013 Yu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
DOI: | 10.1371/journal.pone.0064328 |
Published version: | http://dx.doi.org/10.1371/journal.pone.0064328 |
Appears in Collections: | Aurora harvest 8 Medicine publications |
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hdl_112456.pdf | Published version | 1.27 MB | Adobe PDF | View/Open |
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