Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/113087
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Impact of gastric emptying and small intestinal transit on blood glucose, intestinal hormones, glucose absorption in the morbidly obese |
Author: | Nguyen, Q. Debreceni, T. Burgess, J. Bellon, M. Wishart, J. Standfield, S. Malbert, C.-H. Horowitz, M. |
Citation: | International Journal of Obesity, 2018; 42(9):1556-1564 |
Publisher: | Nature Publishing Group |
Issue Date: | 2018 |
ISSN: | 0307-0565 1476-5497 |
Statement of Responsibility: | Nam Q Nguyen, Tamara L Debreceni, Jenna E Burgess, Max Bellon, Judith Wishart, Scott Standfield, Charles-Henri Malbert, Michael Horowitz |
Abstract: | Objective: This study evaluated gastric emptying (GE) and small intestinal (SI) transit in people with morbid obesity and their relationships to glycaemia, incretin hormones, and glucose absorption Methods: GE and caecal arrival time (CAT) of a mixed meal were assessed in 22 morbidly obese (50.2 ± 2.5 years; 13 F:9 M; BMI: 48.6 ± 1.8 kg/m2) and 10 lean (38.6 ± 8.4 years; 5 F:5 M; BMI: 23.9 ± 0.7 kg/m2) subjects, using scintigraphy. Blood glucose, plasma 3-O-methylglucose, insulin, glucagon, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) were measured. Insulin sensitivity and resistance were also quantified Results: When compared with lean subjects, GE (t50: 60.7 ± 6.5 vs. 41.1 ± 7.3 min; P = 0.04) and CAT (221.5 ± 9.8 vs. 148.0 ± 7.1 min; P = 0.001) of solids were prolonged in morbid obesity. Postprandial rises in GIP (P = 0.001), insulin (P = 0.02), glucose (P = 0.03) and 3-O-methylglucose (P = 0.001) were less. Whereas GLP-1 increased at 45 mins postprandially in lean subjects, there was no increase in the obese (P = 0.04). Both fasting (P = 0.045) and postprandial (P = 0.012) plasma glucagon concentrations were higher in the obese Conclusions: GE and SI transit are slower in the morbidly obese, and associated with reductions in postprandial glucose absorption, and glycaemic excursions, as well as plasma GIP and GLP-1 |
Keywords: | Intestine, Small Humans Obesity, Morbid Gastrointestinal Hormones Blood Glucose Radionuclide Imaging Gastrointestinal Transit Gastric Emptying Adult Middle Aged Female Male |
Description: | Published online: 30 January 2018 |
Rights: | © Macmillan Publishers Limited, part of Springer Nature 2018 |
DOI: | 10.1038/s41366-018-0012-6 |
Published version: | http://dx.doi.org/10.1038/s41366-018-0012-6 |
Appears in Collections: | Aurora harvest 3 Medicine publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.