Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/113274
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Type: Journal article
Title: Facile single-step bioconjugation of the antifungal agent caspofungin onto material surfaces: Via an epoxide plasma polymer interlayer
Author: Michl, T.
Giles, C.
Cross, A.
Griesser, H.
Coad, B.
Citation: RSC Advances, 2017; 7(44):27678-27681
Publisher: Royal Society of Chemistry
Issue Date: 2017
ISSN: 2046-2069
2046-2069
Statement of
Responsibility: 
Thomas D. Michl, Carla Giles, Alasdair T. Cross, Hans J. Griesser and Bryan R. Coad
Abstract: We report a facile, one-step, aqueous surface bioconjugation approach for producing an antifungal surface coating that prevents the formation of fungal biofilms. By direct reaction between surface epoxide groups and amine groups on caspofungin, it avoids the use of secondary chemicals. The coating withstands washing with detergent and reduces the growth of the fungal pathogens Candida albicans by log 6 and Candida glabrata by log 3. Importantly, we show that surface adsorption of albumin does not inhibit the activity of this antifungal coating.
Rights: This journal is © The Royal Society of Chemistry 2017. Open Access. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.
RMID: 0030071975
DOI: 10.1039/c7ra03897f
Grant ID: http://purl.org/au-research/grants/arc/DP150101674
Appears in Collections:Agriculture, Food and Wine publications

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