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Type: Journal article
Title: Midsagittal corpus callosum area and conversion to multiple sclerosis after clinically isolated syndrome: a multicentre Australian cohort study
Author: Odenthal, C.
Simpson, S.
Oughton, J.
van der Mei, I.
Rose, S.
Fripp, J.
Lucas, R.
Taylor, B.
Dear, K.
Ponsonby, A.L.
Coulthard, A.
Ausimmune AusLong Investigator Groups,
Chapman, C.
Dwyer, T.
Kilpatrick, T.
McMichael, T.
Pender, M.P.
Valery, P.
Williams, D.
Broadley, S.
et al.
Citation: Journal of Medical Imaging and Radiation Oncology, 2017; 61(4):453-460
Publisher: Wiley-Blackwell
Issue Date: 2017
ISSN: 1754-9477
Statement of
Cara Odenthal, Steve Simpson Jr, Justin Oughton, Ingrid van der Mei, Stephen Rose, Jurgen Fripp, Robyn Lucas, Bruce Taylor, Keith Dear, Anne-Louise Ponsonby, Alan Coulthard, and the Ausimmune AusLong Investigator Groups
Abstract: Introduction: Patients presenting with clinically isolated syndrome (CIS) may proceed to clinically definite multiple sclerosis (CDMS). Midsagittal corpus callosum area (CCA) is a surrogate marker for callosal atrophy, and can be obtained from a standard MRI study. This study explores the relationship between CCA measured at CIS presentation (baseline) and at 5 years post presentation, with conversion from CIS to CDMS. The association between CCA and markers of disability progression is explored. Methods: Corpus callosum area was measured on MRI scans at presentation and 5-year review following diagnosis of a first demyelinating event, or evidence of progressive MS, in 143 participants in the Ausimmune/AusLong Study. Relationships between CCA (at baseline and follow-up) and clinical outcomes were assessed. Results: Mean CCA at baseline study was 6.63 cm² (SD 1.01). Patients who converted to MS by 5-year review (n = 100) had a significantly smaller mean CCA at follow-up (6.22 vs. 6.74, P = 0.007). Greater CCA reduction was associated with higher annualized relapse rate over follow-up. Conclusion: Baseline CCA obtained from standard MRI protocols may be compared with subsequent MRI examinations as a surrogate for neurodegeneration and cerebral atrophy in patients with MS. This study demonstrates an association between CCA and disability in individuals presenting with CIS who convert to MS.
Keywords: Atrophy; clinically isolated syndrome; corpus callosum; magnetic resonance imaging; multiple sclerosis
Rights: © 2016 The Royal Australian and New Zealand College of Radiologists
DOI: 10.1111/1754-9485.12570
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