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|Title:||Midsagittal corpus callosum area and conversion to multiple sclerosis after clinically isolated syndrome: a multicentre Australian cohort study|
van der Mei, I.
Ausimmune AusLong Investigator Groups
|Citation:||Journal of Medical Imaging and Radiation Oncology, 2017; 61(4):453-460|
|Cara Odenthal, Steve Simpson Jr, Justin Oughton, Ingrid van der Mei, Stephen Rose, Jurgen Fripp, Robyn Lucas, Bruce Taylor, Keith Dear, Anne-Louise Ponsonby, Alan Coulthard, and the Ausimmune AusLong Investigator Groups|
|Abstract:||Introduction: Patients presenting with clinically isolated syndrome (CIS) may proceed to clinically definite multiple sclerosis (CDMS). Midsagittal corpus callosum area (CCA) is a surrogate marker for callosal atrophy, and can be obtained from a standard MRI study. This study explores the relationship between CCA measured at CIS presentation (baseline) and at 5 years post presentation, with conversion from CIS to CDMS. The association between CCA and markers of disability progression is explored. Methods: Corpus callosum area was measured on MRI scans at presentation and 5-year review following diagnosis of a first demyelinating event, or evidence of progressive MS, in 143 participants in the Ausimmune/AusLong Study. Relationships between CCA (at baseline and follow-up) and clinical outcomes were assessed. Results: Mean CCA at baseline study was 6.63 cm² (SD 1.01). Patients who converted to MS by 5-year review (n = 100) had a significantly smaller mean CCA at follow-up (6.22 vs. 6.74, P = 0.007). Greater CCA reduction was associated with higher annualized relapse rate over follow-up. Conclusion: Baseline CCA obtained from standard MRI protocols may be compared with subsequent MRI examinations as a surrogate for neurodegeneration and cerebral atrophy in patients with MS. This study demonstrates an association between CCA and disability in individuals presenting with CIS who convert to MS.|
|Keywords:||Atrophy; clinically isolated syndrome; corpus callosum; magnetic resonance imaging; multiple sclerosis|
|Rights:||© 2016 The Royal Australian and New Zealand College of Radiologists|
|Appears in Collections:||Aurora harvest 8|
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