Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/11371
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Type: Journal article
Title: The Late-Expressed Region of the Temperate Coliphage 186 Genome
Author: Portelli, R.
Dodd, I.
Xue, Q.
Egan, J.
Citation: Virology, 1998; 248(1):117-130
Publisher: ACADEMIC PRESS INC
Issue Date: 1998
ISSN: 0042-6822
1096-0341
Statement of
Responsibility: 
Roberto Portelli, Ian B. Dodd, Qing Xue and J. Barry Egan
Abstract: The late-lytic region of the genome of bacteriophage 186 encodes the phage proteins that synthesize the complex viral particle and lyse the bacterial host. We report the completion of the DNA sequence of the late region and the assignment of 18 previously identified genes to open reading frames in the sequence. The 186 late region is similar to the late region of phage P2, sharing 26 genes of known function: the single gene for activation of late gene transcription, 6 genes for construction of DNA-containing heads, 16 for tail morphogenesis, and 3 for cell lysis. We identified two 186 late genes with unknown function; one is homologous to previously unrecognised genes in P2, HP1, and fCTX, and the other may modulate DNA packaging. The 186 late region, like the rest of the genome, lacks the lysogenic conversion genes that are carried by P2, allowing the 186 late region to be transcribed from only three late promoters rather than four. The relative absence of lysogenic conversion genes in 186 suggests that the two phages have evolved to use the lytic and lysogenic reproductive modes to different extents.
Keywords: Escherichia coli; Bacteriophage P2; Coliphages; Capsid; Viral Proteins; DNA, Viral; Sequence Alignment; Amino Acid Sequence; Base Sequence; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Genes, Viral; Genome, Viral; Open Reading Frames; Molecular Sequence Data; Promoter Regions, Genetic
Description: Copyright 1998 Academic Press
RMID: 0030004363
DOI: 10.1006/viro.1998.9263
Appears in Collections:Biochemistry publications

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