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Type: Journal article
Title: A comparison of right unilateral and sequential bilateral repetitive transcranial magnetic stimulation for major depression: a naturalistic clinical Australian study
Author: Galletly, C.A.
Carnell, B.L.
Clarke, P.
Gill, S.
Citation: The Journal of Electroconvulsive Therapy, 2017; 33(1):58-62
Publisher: Lippincott, Williams & Wilkins
Issue Date: 2017
ISSN: 1095-0680
Statement of
Cherrie A. Galletly, Benjamin L. Carnell, Patrick Clarke, Shane Gill
Abstract: Background: A great deal of research has established the efficacy of repetitive transcranial magnetic stimulation (rTMS) in the treatment of depression. However, questions remain about the optimal method to deliver treatment. One area requiring consideration is the difference in efficacy between bilateral and unilateral treatment protocols. Objective: This study aimed to compare the effectiveness of sequential bilateral rTMS and right unilateral rTMS. Methods: A total of 135 patients participated in the study, receiving either bilateral rTMS (N = 57) or right unilateral rTMS (N = 78). Treatment response was assessed using the Hamilton depression rating scale. Results: Sequential bilateral rTMS had a higher response rate than right unilateral (43.9% vs 30.8%), but this difference was not statistically significant. This was also the case for remission rates (33.3% vs 21.8%, respectively). Controlling for pretreatment severity of depression, the results did not indicate a significant difference between the protocols with regard to posttreatment Hamilton depression rating scale scores. Conclusions: The current study found no statistically significant differences in response and remission rates between sequential bilateral rTMS and right unilateral rTMS. Given the shorter treatment time and the greater safety and tolerability of right unilateral rTMS, this may be a better choice than bilateral treatment in clinical settings.
Keywords: Humans
Treatment Outcome
Depressive Disorder, Major
Psychiatric Status Rating Scales
Middle Aged
Patient Dropouts
Transcranial Magnetic Stimulation
Functional Laterality
Rights: © 2017 Wolters Kluwer Health, Inc. All rights reserved.
DOI: 10.1097/YCT.0000000000000359
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Psychology publications

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