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Type: Journal article
Title: Dynamic mutation: possible mechanisms and significance in human disease
Author: Richards, R.
Sutherland, G.
Citation: Trends in Biochemical Sciences, 1997; 22(11):432-437
Issue Date: 1997
ISSN: 0968-0004
Abstract: Increases in repeat-DNA copy number are the molecular basis of a growing list of human genetic diseases, including fragile X syndrome, myotonic dystrophy, Huntington disease and a form of epilepsy. Repeat-DNA sequences undergo a unique process of dynamic mutation, the common properties of which probably reflect common molecular events. This form of mutation is no longer restricted to trinucleotide repeats, because repeats of different length have been found to undergo expansion.
Keywords: Humans
Genetic Diseases, Inborn
Repetitive Sequences, Nucleic Acid
DOI: 10.1016/S0968-0004(97)01108-0
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Appears in Collections:Aurora harvest 2
Genetics publications

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