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Type: Journal article
Title: Antiemetic therapy in Asia Pacific countries for patients receiving moderately and highly emetogenic chemotherapy-a descriptive analysis of practice patterns, antiemetic quality of care, and use of antiemetic guidelines
Author: Yu, S.
Burke, T.
Chan, A.
Kim, H.
Hsieh, R.
Hu, X.
Liang, J.
Baños, A.
Spiteri, C.
Keefe, D.
Citation: Supportive Care in Cancer, 2015; 23(1):273-282
Publisher: Springer
Issue Date: 2015
ISSN: 0941-4355
Statement of
Shiying Yu, Thomas A. Burke, Alexandre Chan, Hoon-Kyo Kim, Ruey Kuen Hsieh, Xichun Hu, Jin-Tung Liang, Ana Baños, Carmel Spiteri, Dorothy M.K. Keefe
Abstract: Purpose: This paper reports prescribing patterns for prophylaxis of chemotherapy-induced nausea and vomiting (CINV) after highly or moderately emetogenic chemotherapy (HEC or MEC) for cancer in six Asia Pacific countries. Methods: In a prospective noninterventional study, 31 sites in Australia, China, India, Singapore, South Korea, and Taiwan recorded details of CINV prophylaxis for the acute phase (first 24 h) and delayed phase (days 2-5) after single-day HEC or MEC for adult patients. Additional information on CINV prophylactic medications was collected from 6-day patient diaries. Primary antiemetic therapies were defined as corticosteroids, the 5-hydroxytryptamine-3 receptor antagonists (5HT3-RAs), and neurokinin-1 receptor antagonists (NK1-RAs). Results: Evaluable patients in cycle 1 numbered 648 (318 [49%] HEC and 330 [51%] MEC) of mean (SD) age of 56 (12) years, including 58% women. For the acute phase after HEC, overall (and country range), 96% (91-100%) of patients received a 5HT3-RA, 87% (70-100%) a corticosteroid, and 43% (0-91%) an NK1-RA. CINV prophylaxis for the HEC delayed phase was more variable: including 22% (7-65%) 5HT3-RA, 52% (12-93%) corticosteroid, and 46% (0-88%) NK1-RA. For the MEC acute phase, 97% (87-100%) of patients received 5HT3-RA and 86% (73-97%) a corticosteroid. For the MEC delayed phase, 201 patients (61%) received a primary antiemetic, including 5HT3-RA (41%), corticosteroid (37%), and/or NK1-RA (4%). Conclusions: The 5HT3-RAs were prescribed consistently in all countries, while prescribing of other antiemetic therapies was variable, and corticosteroids were under-prescribed for CINV prophylaxis, particularly in the delayed phase.
Keywords: Antiemetic; chemotherapy; nausea; observational; prescribing patterns; vomiting
Rights: © Springer-Verlag Berlin Heidelberg 2014
DOI: 10.1007/s00520-014-2372-3
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