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|Title:||Food restriction alters pregnancy-associated changes in IGF and IGFBP in the guinea pig|
|Citation:||American Journal of Physiology, Endocrinology and Metabolism, 1998; 274(37):E410-E416|
|Publisher:||AMER PHYSIOLOGICAL SOC|
|Abstract:||The effect of moderate food restriction on pregnancy-associated changes in weight gain, body composition, and circulating insulin-like growth factors (IGF) I and II and IGF-binding proteins (IGFBP)-1 through-4 and their relationship was determined in the guinea pig. Pregnancy did not stimulate weight gain but reduced fat deposition in ad libitum-fed animals and increased weight gain and fat deposition in food-restricted animals relative to their respective virginal group. Pregnancy increased the abundance of circulating IGF-I regardless of food intake and increased that of IGF-II in food-restricted animals only. Pregnancy also increased circulating IGFBP-1 and -2 in ad libitum-fed and food-restricted animals and IGFBP-4 in ad libitum-fed animals. Multiple regression analysis showed that maternal weight gain was negatively associated with circulating IGF-II and IGFBP-2. Fetal weight was positively associated with maternal circulating IGF-II and negatively associated with maternal circulating IGFBP-1 and -2. Significant interactions indicate, however, that the role of IGF-II and IGFBP-1 on fetal growth is dependent on the nutritional status of the mother.|
|Keywords:||Placenta; Animals; Guinea Pigs; Weight Gain; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Insulin-Like Growth Factor Binding Proteins; Insulin-Like Growth Factor Binding Protein 1; Insulin-Like Growth Factor Binding Protein 2; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor Binding Protein 4; Food Deprivation; Body Composition; Embryonic and Fetal Development; Pregnancy; Pregnancy, Animal; Female|
|Rights:||© 1998 the American Physiological Society|
|Appears in Collections:||Physiology publications|
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