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|Title:||Liver resection for colorectal cancer metastases: a comparison of outcomes over time in South Australia|
|Citation:||HPB, 2018; 20(4):340-346|
|Asma Sultana, Rosie Meng, Cynthia Piantadosi, Mark Brooke-Smith, John Chen, Paul Dolan, Guy Maddern, Timothy Price, Robert Padbury|
|Abstract:||Background: The aim of the current study was to assess outcomes following liver resection in metastatic CRC (mCRC) in South Australia across two study periods (pre-2006 versus post-2006). Methods: The South Australian (SA) Clinical Registry for mCRC maintains data prospectively on all patients in SA with mCRC diagnosed from 01 February 2006. This data was linked with a prospectively collated database on liver resections for mCRC from 01/01/1992 to 01/02/2006. The primary end point was overall survival. Results: 757 patients underwent liver resection for mCRC. Liver resection was performed on 286 patients pre-2006 and 471 patients post-2006. The median age of the study population was 62 years, and this was similar across both eras. Overall survival was significantly better in the post-2006 era (hazard ratio HR = 0.45, p = 0.001). Complications (59% pre-2006 versus 23% post-2006) and transfusion rates (34% pre-2006 versus 2% post-2006) were significantly higher in the pre-2006 era. Repeat liver resection rates were significantly higher in the post-2006 era (1% pre-2006 versus 10% post-2006). Conclusions: Outcomes following liver resection for mCRC have improved over time, with significantly better overall survival in the post-2006 era compared to pre-2006.|
|Keywords:||Humans; Colorectal Neoplasms; Liver Neoplasms; Treatment Outcome; Hepatectomy; Risk Factors; Time Factors; Databases, Factual; Middle Aged; South Australia; Female; Male|
|Rights:||Crown Copyright © 2017 Published by Elsevier Ltd on behalf of International Hepato-Pancreato-Biliary Association Inc. All rights reserved.|
|Appears in Collections:||Medicine publications|
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