Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/117642
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Type: Journal article
Title: The impact of ten years of HPV vaccination in Australia: what additional disease burden could a 9-valent vaccine prevent?
Author: Cyra, P.
Brotherton, J.
Pillsbury, A.
Jayasinghe, S.
Donovan, B.
Macartney, K.
Marshall, H.
Citation: Eurosurveillance, 2018; 23(41):30-40
Publisher: European Centre for Disease Prevention and Control
Issue Date: 2018
ISSN: 1560-7917
Statement of
Responsibility: 
Cyra Patel, Julia ML Brotherton, Alexis Pillsbury, Sanjay Jayasinghe, Basil Donovan, Kristine Macartney, Helen Marshall
Abstract: BACKGROUND:A National human papilloma virus (HPV) Vaccination Programme for the prevention of HPV infection and associated disease using the quadrivalent HPV vaccine (4vHPV) has been funded and implemented in Australia since 2007, initially for girls only and extended to boys in 2013, with uptake rates among the highest observed worldwide. AIM:We report on the impact of this national programme on HPV prevalence and associated disease burden and estimate the potential impact of adopting a nonavalent HPV (9vHPV) vaccine. METHODS:We performed a non-systematic literature review of studies measuring the burden of HPV-associated disease and infection in Australia before and after introduction of HPV vaccination. We also included key national reports with estimates of HPV-related disease burden. RESULTS:Substantial declines in high-grade cervical disease and genital warts among vaccine-eligible women have been observed. Reductions in genital warts incidence and HPV prevalence among heterosexual men of similar age were observed before introduction of the male vaccination programme, indicating a substantial herd effect. 9vHPV vaccine is expected to prevent up to 90% of cervical and 96% of anal cancers. Of an estimated 1,544 HPV-associated cancers in 2012, 1,242 would have been preventable by the 4vHPV vaccine and an additional 187 anogenital cancers by the 9vHPV vaccine. CONCLUSIONS:Vaccination using 4vHPV vaccine has had a large demonstrable impact on HPV-related disease in Australia. A switch to 9vHPV could further reduce the HPV-associated cancer burden. With continued high coverage among both males and females, elimination of vaccine-type HPV disease seems achievable in Australia.
Keywords: HPV; epidemiology; human papillomavirus; immunisations; vaccine-preventable diseases; vaccines
Rights: This article is copyright of the authors, 2018. This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
DOI: 10.2807/1560-7917.ES.2018.23.41.1700737
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