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Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/117750
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dc.contributor.authorCentenera, M.-
dc.contributor.authorSelth, L.-
dc.contributor.authorEbrahimie, E.-
dc.contributor.authorButler, L.-
dc.contributor.authorTilley, W.-
dc.date.issued2018-
dc.identifier.citationCold Spring Harbor Perspectives in Medicine, 2018; 10(12):1-19-
dc.identifier.issn2157-1422-
dc.identifier.issn2157-1422-
dc.identifier.urihttp://hdl.handle.net/2440/117750-
dc.description.abstractRecent genomic analyses of metastatic prostate cancer have provided important insight into adaptive changes in androgen receptor (AR) signaling that underpin resistance to androgen deprivation therapies. Novel strategies are required to circumvent these AR-mediated resistance mechanisms and thereby improve prostate cancer survival. In this review, we present a summary of AR structure and function and discuss mechanisms of AR-mediated therapy resistance that represent important areas of focus for the development of new therapies.-
dc.description.statementofresponsibilityMargaret M. Centenera, Luke A. Selth, Esmaeil Ebrahimie, Lisa M. Butler and Wayne D. Tilley-
dc.language.isoen-
dc.publisherCold Spring Harbor Laboratory Press-
dc.rightsCopyright © 2018 Cold Spring Harbor Laboratory Press; all rights reserved-
dc.source.urihttp://dx.doi.org/10.1101/cshperspect.a030478-
dc.subjectHumans-
dc.subjectProstatic Neoplasms-
dc.subjectBenzamides-
dc.subjectNitriles-
dc.subjectPhenylthiohydantoin-
dc.subjectAndrostenes-
dc.subjectAndrogen Antagonists-
dc.subjectMolecular Chaperones-
dc.subjectProtein Isoforms-
dc.subjectReceptors, Androgen-
dc.subjectAntineoplastic Agents, Hormonal-
dc.subjectAntineoplastic Combined Chemotherapy Protocols-
dc.subjectGene Amplification-
dc.subjectDrug Resistance, Neoplasm-
dc.subjectMutation-
dc.subjectMale-
dc.subjectMolecular Targeted Therapy-
dc.subjectProstatic Neoplasms, Castration-Resistant-
dc.titleNew opportunities for targeting the androgen receptor in prostate cancer-
dc.typeJournal article-
dc.identifier.doi10.1101/cshperspect.a030478-
dc.relation.granthttp://purl.org/au-research/grants/arc/FT130101004-
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1083961-
pubs.publication-statusPublished-
dc.identifier.orcidCentenera, M. [0000-0002-2206-0632]-
dc.identifier.orcidSelth, L. [0000-0002-4686-1418]-
dc.identifier.orcidEbrahimie, E. [0000-0002-4431-2861]-
dc.identifier.orcidButler, L. [0000-0003-2698-3220]-
dc.identifier.orcidTilley, W. [0000-0003-1893-2626]-
Appears in Collections:Aurora harvest 3
Medicine publications

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