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Type: Journal article
Title: Intraoperative detection of blood vessels with an imaging needle during neurosurgery in humans
Author: Ramakonar, H.
Quirk, B.
Kirk, R.
Li, J.
Jacques, A.
Lind, C.
McLaughlin, R.
Citation: Science Advances, 2018; 4(12):eaav4992-1-eaav4992-10
Publisher: American Association for the Advancement of Science
Issue Date: 2018
ISSN: 2375-2548
Statement of
Hari Ramakonar, Bryden C. Quirk, Rodney W. Kirk, Jiawen Li, Angela Jacques, Christopher R. P. Lind and Robert A. McLaughlin
Abstract: Intracranial hemorrhage can be a devastating complication associated with needle biopsies of the brain. Hemorrhage can occur to vessels located adjacent to the biopsy needle as tissue is aspirated into the needle and removed. No intraoperative technology exists to reliably identify blood vessels that are at risk of damage. To address this problem, we developed an "imaging needle" that can visualize nearby blood vessels in real time. The imaging needle contains a miniaturized optical coherence tomography probe that allows differentiation of blood flow and tissue. In 11 patients, we were able to intraoperatively detect blood vessels (diameter, >500 μm) with a sensitivity of 91.2% and a specificity of 97.7%. This is the first reported use of an optical coherence tomography needle probe in human brain in vivo. These results suggest that imaging needles may serve as a valuable tool in a range of neurosurgical needle interventions.
Keywords: Blood Vessels
Imaging, Three-Dimensional
Magnetic Resonance Imaging
Tomography, Optical Coherence
Biopsy, Needle
Intraoperative Period
ROC Curve
Middle Aged
Optical Imaging
Rights: © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).
DOI: 10.1126/sciadv.aav4992
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