Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/118045
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Type: | Journal article |
Title: | Intraoperative detection of blood vessels with an imaging needle during neurosurgery in humans |
Author: | Ramakonar, H. Quirk, B. Kirk, R. Li, J. Jacques, A. Lind, C. McLaughlin, R. |
Citation: | Science Advances, 2018; 4(12):eaav4992-1-eaav4992-10 |
Publisher: | American Association for the Advancement of Science |
Issue Date: | 2018 |
ISSN: | 2375-2548 2375-2548 |
Statement of Responsibility: | Hari Ramakonar, Bryden C. Quirk, Rodney W. Kirk, Jiawen Li, Angela Jacques, Christopher R. P. Lind and Robert A. McLaughlin |
Abstract: | Intracranial hemorrhage can be a devastating complication associated with needle biopsies of the brain. Hemorrhage can occur to vessels located adjacent to the biopsy needle as tissue is aspirated into the needle and removed. No intraoperative technology exists to reliably identify blood vessels that are at risk of damage. To address this problem, we developed an "imaging needle" that can visualize nearby blood vessels in real time. The imaging needle contains a miniaturized optical coherence tomography probe that allows differentiation of blood flow and tissue. In 11 patients, we were able to intraoperatively detect blood vessels (diameter, >500 μm) with a sensitivity of 91.2% and a specificity of 97.7%. This is the first reported use of an optical coherence tomography needle probe in human brain in vivo. These results suggest that imaging needles may serve as a valuable tool in a range of neurosurgical needle interventions. |
Keywords: | Blood Vessels Brain Humans Imaging, Three-Dimensional Magnetic Resonance Imaging Tomography, Optical Coherence Biopsy, Needle Intraoperative Period ROC Curve Neurosurgery Aged Middle Aged Female Male Optical Imaging |
Rights: | © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). |
DOI: | 10.1126/sciadv.aav4992 |
Grant ID: | http://purl.org/au-research/grants/arc/CE140100003 http://purl.org/au-research/grants/arc/DP150104660 http://purl.org/au-research/grants/arc/DP160104175 |
Published version: | http://dx.doi.org/10.1126/sciadv.aav4992 |
Appears in Collections: | Aurora harvest 3 Medicine publications |
Files in This Item:
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hdl_118045.pdf | Published version | 3.92 MB | Adobe PDF | View/Open |
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