Please use this identifier to cite or link to this item:
Scopus Web of Science® Altmetric
Full metadata record
DC FieldValueLanguage
dc.contributor.authorZuo, T.-
dc.contributor.authorLi, X.-
dc.contributor.authorChang, Y.-
dc.contributor.authorDuan, G.-
dc.contributor.authorYu, L.-
dc.contributor.authorZheng, R.-
dc.contributor.authorXue, C.-
dc.contributor.authorTang, Q.-
dc.identifier.citationFood and Function, 2015; 6(2):415-422-
dc.description.abstractMucositis is a common problem that results from cancer chemotherapy and is a cause of significant morbidity and occasional mortality. Its prevention and successful treatment can significantly enhance the quality of life of patients and improve their survival. Sea cucumber is a traditional aquatic food that has both nutritional and medicinal value. The polysaccharide fucoidan from the sea cucumber (SC-FUC) has various bioactivities. We examined the protective effect of different molecular weights (MWs 50 kDa-500 kDa) of fucoidan from the sea cucumber, Acaudina molpadioides, in a mouse model of cyclophosphamide (Cy)-induced intestinal mucositis. Results showed that the oral administration of SC-FUC markedly reversed Cy-induced damage in the mice. The sea cucumber fucoidan notably increased the ratio of the length of the intestinal villus to the crypt depth and ameliorated the IFN-γ/IL-4 ratio that signifies Th1/Th2 immune balance. Moreover, all the fucoidans in this study enhanced the expression of IgA by accelerating the expression of IL-6 that is probably combined with IL-10. The differing effects of the varied molecular weights of fucoidan may be due to the difference in the efficiency of absorption. This is a novel study on the potential preventive effects of SC-FUC on intestinal mucositis that may be related to the efficiency of its absorption during digestion. Sea cucumber fucoidan (SC-FUC) may be used as a potential food supplement to prevent chemotherapeutic mucositis.-
dc.description.statementofresponsibilityTao Zuo, Xuemin Li, Yaoguang Chang, Gaofei Duan, Long Yu, Rong Zheng, Changhu Xuea and Qingjuan Tang-
dc.publisherRoyal Society of Chemistry-
dc.rightsThis journal is © The Royal Society of Chemistry 2015-
dc.subjectGene Expression Regulation-
dc.titleDietary fucoidan of Acaudina molpadioides and its enzymatically degraded fragments could prevent intestinal mucositis induced by chemotherapy in mice-
dc.typeJournal article-
dc.identifier.orcidYu, L. [0000-0002-6020-3905]-
Appears in Collections:Agriculture, Food and Wine publications
Aurora harvest 8

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.