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https://hdl.handle.net/2440/11866
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Type: | Journal article |
Title: | The role of n-6 polyunsaturated fat in stable asthmatics |
Author: | Coates, A. Noakes, M. Clifton, P. |
Citation: | Journal of Asthma, 2001; 38(4):311-319 |
Publisher: | Marcel Dekker Inc |
Issue Date: | 2001 |
ISSN: | 0277-0903 1532-4303 |
Abstract: | We investigated in a clinical setting whether increased intake of linoleic acid alters respiratory function in 26 mild asthmatics. Subjects completed a 16-week-dietary intervention comprising 8 weeks eating an enriched n-6 polyunsaturated fat diet (9.2% energy from linoleic acid) and consuming either a high monounsaturated or saturated fat diet in a random cross-over resign for 8 weeks. Neither FEV1 nor PC20 values changed significantly after increased linoleic acid consumption when compared with the other diets. Increased consumption of linoleic acid caused a 20% rise (p < or = 0.01) in plasma linoleic acid, a 38% decrease (p < or = 0.01) in plasma eicosapentaenoic acid, but no change in arachidonic acid. There were no changes in symptom scores or bronchodilator use. |
Keywords: | Humans Asthma Histamine Margarine Fatty Acids Linoleic Acid Peak Expiratory Flow Rate Forced Expiratory Volume Cross-Over Studies Middle Aged Female Male |
DOI: | 10.1081/JAS-100002297 |
Published version: | http://dx.doi.org/10.1081/jas-100002297 |
Appears in Collections: | Aurora harvest 7 Physiology publications |
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