Cancer-associated fibroblasts in gastrointestinal cancer
Date
2019
Authors
Kobayashi, H.
Enomoto, A.
Woods, S.L.
Burt, A.D.
Takahashi, M.
Worthley, D.L.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
Nature Reviews Gastroenterology and Hepatology, 2019; 16(5):282-295
Statement of Responsibility
Hiroki Kobayashi, Atsushi Enomoto, Susan L. Woods, Alastair D. Burt, Masahide Takahashi and Daniel L. Worthley
Conference Name
Abstract
The tumour microenvironment, also termed the tumour stroma or tumour mesenchyme, includes fibroblasts, immune cells, blood vessels and the extracellular matrix and substantially influences the initiation, growth and dissemination of gastrointestinal cancer. Cancer-associated fibroblasts (CAFs) are one of the critical components of the tumour mesenchyme and not only provide physical support for epithelial cells but also are key functional regulators in cancer, promoting and retarding tumorigenesis in a context-dependent manner. In this Review, we outline the emerging understanding of gastrointestinal CAFs with a particular emphasis on their origin and heterogeneity, as well as their function in cancer cell proliferation, tumour immunity, angiogenesis, extracellular matrix remodelling and drug resistance. Moreover, we discuss the clinical implications of CAFs as biomarkers and potential targets for prevention and treatment of patients with gastrointestinal cancer.
School/Discipline
Dissertation Note
Provenance
Description
Access Status
Rights
© 2019, Springer Nature