Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/119475
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Type: Journal article
Title: The effects of long-term CPAP on weight change in patients with comorbid OSA and cardiovascular disease: data from the SAVE trial
Author: Ou, Q.
Chen, B.
Loffler, K.
Luo, Y.
Zhang, X.
Chen, R.
Wang, Q.
Drager, L.
Lorenzi-Filho, G.
Hlavac, M.
McArdle, N.
Mukherjee, S.
Mediano, O.
Barbe, F.
Anderson, C.
McEvoy, R.
Woodman, R.
Citation: Chest, 2019; 155(4):720-729
Publisher: Elsevier
Issue Date: 2019
ISSN: 0012-3692
1931-3543
Statement of
Responsibility: 
Qiong Ou, Baixin Chen, Kelly A. Loffler, Yuanming Luo, Xilong Zhang, Rui Chen, Qian Wang, Luciano F. Drager, Geraldo Lorenzi-Filho, Michael Hlavac, Nigel McArdle, Sutapa Mukherjee, Olga Mediano, Ferran Barbe, Craig S. Anderson, R. Doug McEvoy, Richard J. Woodman (on behalf of the SAVE investigators)
Abstract: Background: Although recent evidence suggests that OSA treatment may cause weight gain, the long-term effects of CPAP on weight are not well established. Methods: This study was a post hoc analysis of the Sleep Apnea Cardiovascular Endpoints (SAVE) study, a multicenter, randomized trial of CPAP plus standard care vs standard care alone in adults with a history of cardiac or cerebrovascular events and moderate to severe OSA. Participants with weight, BMI, and neck and waist circumferences measured at baseline and during follow-up were included. Linear mixed models were used to examine sex-specific temporal differences, and a sensitivity analysis compared high CPAP adherers (≥ 4 h per night) with propensity-matched control participants. Results: A total of 2,483 adults (1,248 in the CPAP group and 1,235 in the control group) were included (mean 6.1 ± 1.5 measures of weight available). After a mean follow-up of 3.78 years, there was no difference in weight change between the CPAP and control groups, for male subjects (mean [95% CI] between-group difference, 0.07 kg [-0.40 to 0.54]; P = .773) or female subjects (mean [95% CI] between-group difference, -0.14 kg [-0.37 to 0.09]; P = .233). Similarly, there were no significant differences in BMI or other anthropometric measures. Although male participants who used CPAP ≥ 4 h per night gained slightly more weight than matched male control subjects without CPAP (mean difference, 0.38 kg [95% CI, 0.04 to 0.73]; P = .031), there were no between-group differences in other anthropometric variables, nor were there any differences between female high CPAP adherers and matched control subjects. Conclusions: Long-term CPAP use in patients with comorbid OSA and cardiovascular disease does not result in clinically significant weight change.
Keywords: CPAP; long-term; OSA; weight
Rights: © 2018 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.
RMID: 0030107779
DOI: 10.1016/j.chest.2018.08.1082
Grant ID: http://purl.org/au-research/grants/nhmrc/1006501
http://purl.org/au-research/grants/nhmrc/1060078
Appears in Collections:Medicine publications

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